A comprehensive environmental genomic study of socially important diseases in Russia and the EU

Starting date
April 16, 2009
Duration (months)
24
Departments
Diagnostics and Public Health
Managers or local contacts
De Marco Roberto

Name of the coordinating person: Dr Thomas Illig
Participant organisation name:
HelmholtzZentrum München
Kursk State Medical University
Institute of Medical Genetics, Tomsk
Institute of Biochemistry and Genetics, Ufa
University of Verona
Engedi Science Ltd

Genome wide analysis has been conducted for several important diseases in large populations, but there are many discrepancies between the studies. A possible reason is the lack of analysis of gene-environment interactions. Furthermore, there is generally little information provided on the functional role of identified genes. In EURUGEN, chronic obstructive pulmonary disease, essential hypertension and type 2 diabetes, all important in Russia and the EU, will be investigated in a multi-center case control study using genome-wide analysis. The samples will be analysed with high throughput genotyping, deep sequencing and metabolomics to provide useful data for a functional genomics approach. In addition, environmental and lifestyle data will be collected to provide a comprehensive description of gene-environment interactions related to each disease. Correlations will be made not only with disease onset but also co-morbidities between the three diseases and their complications. The project will take initial steps towards functional analysis of selected polymorphisms and will develop predictive models for use by epidemiologists and clinicians.

Sponsors:

7PQ VALUTATI POSITIVAMENTE
Funds: requested
Syllabus: INTERNAZ - Progetti di Internazionalizzazione

Project participants

Simone Accordini
Associate Professor
Lucia Cazzoletti
Assistant Professor
Roberto De Marco
Francesca Locatelli
Assistant Professor
Alessandro Marcon
Temporary Assistant Professor
Giuseppe Verlato
Full Professor
Maria Elisabetta Zanolin
Associate Professor

Activities

Research facilities