Resolve chronic inflammation and achieve healthy ageing by understanding no-regenerative repair

Starting date
April 1, 2008
Duration (months)
60
Managers or local contacts
Chilosi Marco

RESOLVE has been outlined to better understand the regulatory networks that control the developmental processes in organ repair and to identify mechanisms which cause the termination of regular organ development leading to fibroproliferative wound healing. Fibroproliferative wound healing represents a major pathology in elderly people shiftling regular organ development into progressive organ fibrosis ith complete loss of organ function. Based on the identification of valuated molecular targets of fibroproliferative repair, RESOLVE aims to create suitable treatment strategies to achieve healthy ageing in the elderly. In doing so, RESOLVE will create a significant impact on life quality of elderly people. RESOLVE's outcomes will strenghten the competitiveness of European science and biotechnology industry and contribute to cost saving strategies in the health sector.
RESOLVE's structured scientific approach combines as yet fragmented fields of research using modern organism which represent(a) different forms of wound healing, (b) different human diseases and (c) different genetic backgrounds, guaranteeing social and scientific relevance, modularity, of research and the integration of existing biological knowledge, technical expertise and medical experience. In addition sequential generation of data during improvement of Worsening ensures clinical relevance and leads to a stringent exploitation strategy. The sustainable outcomes of RESOLVE's efforts will be:(A) the urgently needed diagnostic to tool for fibroproliferative wound healing invarious organ (B) highly valuable transgenic animals offering test systems for fibroproliferative wound healing, and (C)a characterization of compounds capable of interfering with targets involved in fibroproliferative repair.

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