Pubblicazioni

Autori:

Manfrin, Erminia; Perini, Claudia; Di Stefano, Serena; Bernardoni, Laura; Parisi, Alice; Frulloni, Luca; Sina, Sokol; Remo, Andrea; Gabbrielli, Armando; Crinò, Stefano Francesco

Titolo:

Pseudo solid-appearing pancreatic serous microcystic adenomas: Histologic diagnosis with the EUS core biopsy fork-tip needle

Anno:

2019

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

ENDOSCOPIC ULTRASOUND

ISSN Rivista:

2303-9027

N° Volume:

8

Numero o Fascicolo:

5

Intervallo pagine:

334-341-341

Parole chiave:

EUS; EUS fine-needle biopsy; EUS-FNA; pancreatic cysts; pancreatic neuroendocrine; pancreatic solid neoplasm; serous cystadenoma; serous cystic neoplasia

Breve descrizione dei contenuti:

Background and Objectives: Despite rarely, serous cystic adenoma (SCA) can assume a pseudo-solid aspect mimicking other pancreatic neoplasm as neuroendocrine tumor. EUS-FNA cytology has low diagnostic accuracy due to the scant cellularity of the collected samples. Histological diagnosis is usually made after resection. Recently, end-cutting needles for EUS-fine-needle biopsy (EUS-FNB), which obtain tissue cores by penetrating the lesions, have been developed. We aimed to assess the capability of EUS-FNB with SharkCore (TM) needles in the preoperative diagnosis of serous cystic adenoma pseudo-solid-appearing on imaging (Sa-SCA). Materials and Methods: Between January 2016 and January 2018, data from consecutive adult patients, who were referred for EUS-FNB of a solid pancreatic lesion and were diagnosed with having SCA, were retrieved from a single-center institutional database. Results: Two patients were excluded because of microcystic aspect at EUS. Histological diagnosis of SCA was made by EUS-FNB in the remaining 7 patients (5 females; mean age of 62.5 years). Lesions (mean size of 19.8 mm) were hypervascular on cross-sectional imaging, slightly hyperdense magnetic resonance imaging with T2-weighted images can, and negative at Ga-68-somatostatin receptor positron emission tomography and (18)fluoro-deoxyglucose positron emission tomography. EUS-FNB samples were judged adequate for a definitive diagnosis in all cases, achieving specimens suitable for histological evaluation and several ancillary stains. Histochemical positivity for periodic acid-Schiff (PAS) and PAS with diastase digestion was observed in 7/7 cases. Immunohistochemical positivity for alpha-inhibin (7/7), GLUT1 (6/6), MUC6 (5/5), and negativity for synaptophysin (7/7) and chromogranin A (2/2) favored SCA diagnosis. Conclusions: In the case of preoperative workup suspected for Sa-SCA, a "forward acquiring" needle could improve the rate of preoperative histological diagnosis.

Id prodotto:

114400

Handle IRIS:

11562/1017955

ultima modifica:

13 novembre 2022

Citazione bibliografica:

Manfrin, Erminia; Perini, Claudia; Di Stefano, Serena; Bernardoni, Laura; Parisi, Alice; Frulloni, Luca; Sina, Sokol; Remo, Andrea; Gabbrielli, Armando; Crinò, Stefano Francesco, Pseudo solid-appearing pancreatic serous microcystic adenomas: Histologic diagnosis with the EUS core biopsy fork-tip needle «ENDOSCOPIC ULTRASOUND» , vol. 8 , n. 5 , 2019 , pp. 334-341-341

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