Pubblicazioni

Autori:

Luchini, Claudio; Paolino, Gaetano; Mattiolo, Paola; Piredda, Maria L; Cavaliere, Alessandro; Gaule, Marina; Melisi, Davide; Salvia, Roberto; Malleo, Giuseppe; Shin, Jae Il; Cargnin, Sarah; Terrazzino, Salvatore; Lawlor, Rita T; Milella, Michele; Scarpa, Aldo

Titolo:

KRAS wild-type pancreatic ductal adenocarcinoma: molecular pathology and therapeutic opportunities

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ISSN Rivista:

1756-9966

N° Volume:

39

Numero o Fascicolo:

1

Intervallo pagine:

1-10

Parole chiave:

BRAF; KRAS; MSI; dMMR; fusion genes; pancreatic cancer

Breve descrizione dei contenuti:

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, whose main molecular trait is the MAPK pathway activation due to KRAS mutation, which is present in 90% of cases.The genetic landscape of KRAS wild type PDAC can be divided into three categories. The first is represented by tumors with an activated MAPK pathway due to BRAF mutation that occur in up to 4% of cases. The second includes tumors with microsatellite instability (MSI) due to defective DNA mismatch repair (dMMR), which occurs in about 2% of cases, also featuring a high tumor mutational burden. The third category is represented by tumors with kinase fusion genes, which marks about 4% of cases. While therapeutic molecular targeting of KRAS is an unresolved challenge, KRAS-wild type PDACs have potential options for tailored treatments, including BRAF antagonists and MAPK inhibitors for the first group, immunotherapy with anti-PD-1/PD-L1 agents for the MSI/dMMR group, and kinase inhibitors for the third group.This calls for a complementation of the histological diagnosis of PDAC with a routine determination of KRAS followed by a comprehensive molecular profiling of KRAS-negative cases.

Note:

Published: OCT 28 2020

Id prodotto:

117160

Handle IRIS:

11562/1028368

ultima modifica:

18 novembre 2022

Citazione bibliografica:

Luchini, Claudio; Paolino, Gaetano; Mattiolo, Paola; Piredda, Maria L; Cavaliere, Alessandro; Gaule, Marina; Melisi, Davide; Salvia, Roberto; Malleo, Giuseppe; Shin, Jae Il; Cargnin, Sarah; Terrazzino, Salvatore; Lawlor, Rita T; Milella, Michele; Scarpa, Aldo, KRAS wild-type pancreatic ductal adenocarcinoma: molecular pathology and therapeutic opportunities «JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH» , vol. 39 , n. 1 , 2020 , pp. 1-10

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