Pubblicazioni

Autori:

Porru, Stefano; Monaco, Maria Grazia Lourdes; Carta, Angela; Spiteri, Gianluca; Parpaiola, Marco; Battaggia, Andrea; Galligioni, Giulia; Ferrazzi, Beatrice; Lo Cascio, Giuliana; Gibellini, Davide; Peretti, Angelo; Brutti, Martina; Tardivo, Stefano; Ghirlanda, Giovanna; Verlato, Giuseppe; Gaino, Stefania; Peserico, Denise; Bassi, Antonella; Lippi, Giuseppe

Titolo:

SARS-CoV-2 infection in health workers: analysis from Verona SIEROEPID Study during the pre-vaccination era

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH

ISSN Rivista:

1660-4601

N° Volume:

18

Numero o Fascicolo:

6446

Intervallo pagine:

1-11

Parole chiave:

SARS-CoV-2 infection; health workers; serosurvey

Breve descrizione dei contenuti:

Background: To report the baseline phase of the SIEROEPID study on SARS-CoV-2 infection seroprevalence among health workers at the University Hospital of Verona, Italy, between spring and fall 2020; to compare performances of several laboratory tests for SARS-CoV-2 antibody detection. Methods: 5299 voluntary health workers were enrolled from 28 April 2020 to 28 July 2020 to assess immunological response to SARS-CoV-2 infection throughout IgM, IgG and IgA serum levels titration by four laboratory tests. Association of antibody titre with several demographic variables, swab tests and performance tests (sensitivity, specificity, and agreement) were statistically analyzed. Results: The overall seroprevalence was 6%, considering either IgG and IgM, and 4.8% considering IgG. Working in COVID-19 Units was not associated with a statistically significant increase in the number of infected workers. Cohen's kappa of agreement between MaglumiTM and VivaDiagTM was quite good when considering IgG only (Cohen's kappa = 78.1%, 95% CI 74.0-82.0%), but was lower considering IgM (Cohen's kappa = 13.3%, 95% CI 7.8-18.7%). Conclusion: The large sample size with high participation (84.7%), the biobank and the longitudinal design were significant achievements, offering a baseline dataset as the benchmark for risk assessment, health surveillance and management of SARS-CoV-2 infection for the hospital workforce, especially considering the ongoing vaccination campaign. Study results support the national regulator guidelines on using swabs for SARS-CoV-2 screening with health workers and using the serological tests to contribute to the epidemiological assessment of the spread of the virus.

Pagina Web:

https://doi.org/10.3390/ijerph18126446

Id prodotto:

121733

Handle IRIS:

11562/1045712

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Porru, Stefano; Monaco, Maria Grazia Lourdes; Carta, Angela; Spiteri, Gianluca; Parpaiola, Marco; Battaggia, Andrea; Galligioni, Giulia; Ferrazzi, Beatrice; Lo Cascio, Giuliana; Gibellini, Davide; Peretti, Angelo; Brutti, Martina; Tardivo, Stefano; Ghirlanda, Giovanna; Verlato, Giuseppe; Gaino, Stefania; Peserico, Denise; Bassi, Antonella; Lippi, Giuseppe, SARS-CoV-2 infection in health workers: analysis from Verona SIEROEPID Study during the pre-vaccination era «INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH» , vol. 18 , n. 6446 , 2021 , pp. 1-11

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo