Pubblicazioni

Autori:

Cherubini, Sabrina; Perilli, Mariagrazia; Azzini, Anna Maria; Tacconelli, Evelina; Maccacaro, Laura; Bazaj, Alda; Naso, Laura; Amicosante, Gianfranco; Ltcf-Veneto Working Group, Null; Lo Cascio, Giuliana; Piccirilli, Alessandra

Titolo:

Resistome and Virulome of Multi-Drug Resistant E. coli ST131 Isolated from Residents of Long-Term Care Facilities in the Northern Italian Region

Anno:

2022

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

DIAGNOSTICS

ISSN Rivista:

2075-4418

N° Volume:

12

Numero o Fascicolo:

1

Intervallo pagine:

1-11

Parole chiave:

E. coli; WGS; antibiotic resistance genes; virulome; β-lactamases

Breve descrizione dei contenuti:

: Long-term care facilities (LTCFs) are important reservoirs of antimicrobial-resistant (AMR) bacteria which colonize patients transferred from the hospital, or they may emerge in the facility as a result of mutation or gene transfer. In the present study, we characterized, from a molecular point of view, 43 E. coli strains collected from residents of LTCFs in Northern Italy. The most common lineage found was ST131, followed by sporadic presence of ST12, ST69, ST48, ST95, ST410 and ST1193. All strains were incubators of several virulence factors, with iss, sat, iha and senB being found in 84%, 72%, 63% and 51% of E. coli, respectively. Thirty of the ST131 analyzed were of the O25b:H4 serotype and H30 subclone. The ST131 isolates were found to be mainly associated with IncF plasmids, CTX-M-1, CTX-M-3, CTX-M-15, CTX-M-27 and gyrA/parC/parE mutations. Metallo-β-lactamases were not found in ST131, whereas KPC-3 carbapenemase was found only in two ST131 and one ST1193. In conclusion, we confirmed the spread of extended-spectrum β-lactamase genes in E. coli ST131 isolated from colonized residents living inside LTCFs. The ST131 represents an incubator of fluoroquinolones, aminoglycosides and other antibiotic resistance genes in addition to different virulence factors.

Id prodotto:

124692

Handle IRIS:

11562/1056901

ultima modifica:

14 novembre 2022

Citazione bibliografica:

Cherubini, Sabrina; Perilli, Mariagrazia; Azzini, Anna Maria; Tacconelli, Evelina; Maccacaro, Laura; Bazaj, Alda; Naso, Laura; Amicosante, Gianfranco; Ltcf-Veneto Working Group, Null; Lo Cascio, Giuliana; Piccirilli, Alessandra, Resistome and Virulome of Multi-Drug Resistant E. coli ST131 Isolated from Residents of Long-Term Care Facilities in the Northern Italian Region «DIAGNOSTICS» , vol. 12 , n. 1 , 2022 , pp. 1-11

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