Pubblicazioni

Autori:

Porcaro, Antonio Benito; Costantino, Sonia; Brancelli, Claudio; Baielli, Alberto; Artoni, Francesco; Montanaro, Francesca; Gallina, Sebastian; Bianchi, Alberto; Serafin, Emanuele; Veccia, Alessandro; Franceschini, Andrea; Rizzetto, Riccardo; Brunelli, Matteo; Migliorini, Filippo; Bertolo, Riccardo Giuseppe; Cerruto, Maria Angela; Antonelli, Alessandro

Titolo:

2012 Briganti nomogram predict prostate cancer progression in EAU intermediate risk with unfavorable tumor grade: A single center experience

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

Sì

Nome rivista:

Urologia

ISSN Rivista:

0391-5603

N° Volume:

91

Numero o Fascicolo:

3

Intervallo pagine:

531-537

Parole chiave:

Briganti’s 2012 nomogram predicting lymph node invasion; European Association of Urology; Prostate cancer; adverse tumor grade; biochemical recurrence; intermediate-risk prostate cancer; pelvic lymph node invasion; prostate cancer nomogram; prostate cancer progression; robot assisted radical prostatectomy; unfavorable prognosis

Breve descrizione dei contenuti:

Background: To investigate the potential prognostic impact of Briganti's 2012 nomogram in EAU intermediate-risk patients presenting with an unfavorable tumor grade and treated with robot-assisted radical prostatectomy, eventually associated with extended pelvic lymph node dissection. Materials and methods: From January 2013 to December 2021, the study included 179 EAU intermediate-risk patients presenting with an unfavorable tumor grade (ISUP 3), eventually associated with a PSA of 10-20 ng/ml and/or cT-2b. Briganti's 2012 nomogram was assessed as both a continuous and dichotomous variable, categorized according to the median (risk score ⩾7% vs <7%). Disease progression, defined as biochemical recurrence and/or metastatic progression, was evaluated using Cox proportional hazards in both univariate and multivariate analyses. Results: Disease progression occurred in 43 (24%) patients after a median (95% CI) follow-up of 78 (65.7-88.4) months. The nomogram risk score predicted disease progression, evaluated both as a continuous variable (hazard ratio, HR = 1.064; 95% CI: 1.035-1.093; p < 0.0001) and as a categorical variable (HR = 3.399; 95% CI: 1.740-6.638; p < 0.0001). This association was confirmed in multivariate analysis, where hazard ratios remained consistent even after adjusting for clinical and pathological factors. Conclusions: In EAU intermediate-risk PCa cases presenting with an unfavorable tumor grade and treated surgically, Briganti's 2012 nomogram was associated with disease progression after surgery. Consequently, as the nomogram risk score increased, patients were more likely to experience PCa progression, facilitating the stratification of the patient population into distinct prognostic subgroups.

Note:

Epub 2024 May 23

Pagina Web:

https://journals.sagepub.com/doi/10.1177/03915603241252911?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub 0pubmed

Id prodotto:

140003

Handle IRIS:

11562/1127908

ultima modifica:

6 ottobre 2024

Citazione bibliografica:

Porcaro, Antonio Benito; Costantino, Sonia; Brancelli, Claudio; Baielli, Alberto; Artoni, Francesco; Montanaro, Francesca; Gallina, Sebastian; Bianchi, Alberto; Serafin, Emanuele; Veccia, Alessandro; Franceschini, Andrea; Rizzetto, Riccardo; Brunelli, Matteo; Migliorini, Filippo; Bertolo, Riccardo Giuseppe; Cerruto, Maria Angela; Antonelli, Alessandro, 2012 Briganti nomogram predict prostate cancer progression in EAU intermediate risk with unfavorable tumor grade: A single center experience «Urologia» , vol. 91 , n. 3 , 2024 , pp. 531-537

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo