Pubblicazioni

Autori:

Zoppini, Giacomo; Verlato, Giuseppe; Targher, Giovanni; Casati, Stefano; Gusson, Elena; Biasi, V.; Perrone, F.; Bonora, Enzo; Muggeo, Michele

Titolo:

Is fasting glucose variability a risk factor for retinopathy in people with type 2 diabetes?

Anno:

2009

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Nutrition in Metabolic and Cardiovascular Diseases

ISSN Rivista:

0939-4753

N° Volume:

19

Numero o Fascicolo:

5

Intervallo pagine:

334-339

Parole chiave:

type 2 diabetes; retinopathy; glucose variability

Breve descrizione dei contenuti:

AIMS: Fasting plasma glucose variability strongly predicts the incidence of cardiovascular events in type 2 diabetic patients. We prospectively assessed whether fasting plasma glucose variability predicts the development/progression of retinopathy in a large cohort of type 2 diabetic outpatients. METHODS: In the period 1996-1999, 1019 type 2 diabetic participants (aged 69+/-11 years) in the Verona Diabetes Study underwent at least 3 fasting plasma glucose (FPG) determinations and an eye examination by retinography. Of these, 746 underwent a 2nd eye examination in the period 2000-2004, while 273 did not (102 patients had died before undergoing the 2nd eye examination). For each patient, the mean (M-FPG) and the coefficient of variation of FPG (CV-FPG) were computed. RESULTS: By the 2nd eye examination, 124 patients had either developed new retinopathy (79 patients) or progressed to a more severe degree of retinopathy (45 patients). In a multivariable logistic regression analysis, the development/progression of retinopathy was independently predicted by average glycaemia over time, expressed as glycated haemoglobin (odds ratio [OR] 1.82, 95%CI 1.40-2.38 for 1 SD increase) or M-FPG (OR 1.88, 1.47-2.41), but not by CV-FPG. Among other independent variables, HDL-cholesterol was inversely associated with the development/progression of retinopathy. CONCLUSIONS: These results suggest that in elderly type 2 diabetic patients the magnitude of hyperglycaemia, but not fasting plasma glucose variability, strongly predicts the development/progression of diabetic retinopathy independently of other known risk factors.

Pagina Web:

https://doi.org/10.1016/j.numecd.2008.02.007

Id prodotto:

49426

Handle IRIS:

11562/315178

depositato il:

10 giugno 2009

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Zoppini, Giacomo; Verlato, Giuseppe; Targher, Giovanni; Casati, Stefano; Gusson, Elena; Biasi, V.; Perrone, F.; Bonora, Enzo; Muggeo, Michele, Is fasting glucose variability a risk factor for retinopathy in people with type 2 diabetes? «Nutrition in Metabolic and Cardiovascular Diseases» , vol. 19 , n. 5 , 2009 , pp. 334-339

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