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Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats  (2011)

Authors:
Giarola A; Auber A; Chiamulera C
Title:
Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats
Year:
2011
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
Elettronico
Referee:
Name of journal:
BEHAVIOURAL PHARMACOLOGY
ISSN of journal:
0955-8810
N° Volume:
22
Number or Folder:
1
:
Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320
Page numbers:
1-6
Keyword:
acetylcholinesterase inhibitor; drug discrimination; galantamine; nicotine; physostigmine; rat; tacrin
Short description of contents:
Acetylcholinesterase inhibitors (AChE-Is), galantamine, physostigmine and tacrine, enhance central levels of synaptic acetylcholine. Galantamine and physostigmine, but not tacrine, exhibit allosteric potentiation ligand (APL) properties on nicotinic acetylcholine receptors. The purpose of this study was to investigate whether AChE-Is with nicotinic acetylcholine receptor-positive allosteric modulator properties generalize to the discriminative stimulus effect of nicotine in rats. A two-lever operant conditioning paradigm was used in which rats were trained to discriminate nicotine (0.2 mg/kg/ml intraperitoneally) from saline. After training, generalization tests were carried out with galantamine (1, 3 or 5 mg/kg intraperitoneally), physostigmine (0.05, 0.1 or 0.2 mg/kg subcutaneously) or tacrine (0.625, 1.25 or 2.5 mg/kg subcutaneously) given as a single presession administration. Galantamine, physostigmine or tacrine produced a partial generalization of 62.2%, 55.1% or 43.6% , respectively, on the nicotine-appropriate lever compared with 100% partial generalization induced by the nicotine-training dose. High doses of galantamine, physostigmine or tacrine produced small but significant decreases in operant response rate, suggesting a possible underestimation of the degree of generalization. Our study showed that these three AChE-Is partially generalized to the nicotine stimulus without a significant distinction between AChE-Is with or without APL properties. These findings suggest that the APL property is not necessary for inducing nicotine-like effects in vivo in this behavioural paradigm.
Product ID:
58411
Handle IRIS:
11562/346588
Deposited On:
December 6, 2010
Last Modified:
December 4, 2019
Bibliographic citation:
Giarola A; Auber A; Chiamulera C, Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats «BEHAVIOURAL PHARMACOLOGY» , vol. 22 , n. 12011pp. 1-6

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