Pubblicazioni

Autori:

Zen, Y; Pedica, Federica; Patcha, Vr; Capelli, Paola; Zamboni, Giuseppe; Casaril, Andrea; Quaglia, A; Nakanuma, Y; Heaton, N; Portmann, B.

Titolo:

Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct

Anno:

2011

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Modern Pathology

ISSN Rivista:

0893-3952

N° Volume:

24

Numero o Fascicolo:

8

Intervallo pagine:

1079-1089

Parole chiave:

Mucinous cystic neoplasms; liver; intraductal papillay neoplasmas of the bile duct

Breve descrizione dei contenuti:

Mucinous cystic neoplasm of the liver has been a controversial entity, in particular, regarding differentiation from intraductal papillary neoplasm of the bile duct. In this study, we compared the characteristics of hepatic mucinous cystic neoplasms with ovarian-like stroma (n=29) to those of cyst-forming intraductal papillary neoplasms of the bile duct (n=12). Radiological or macroscopic appearance, histological grade of malignancy, and postoperative clinical course were recorded. Immunohistochemistry for biliary or gastrointestinal markers was performed to characterize cell phenotypes. The patients with hepatic mucinous cystic neoplasm were all female and ranged in age from 21 to 67 years, which was significantly younger than that in the patients with biliary intraductal papillary neoplasm. Eighteen mucinous cystic neoplasms (76%) were located in the left lobe, with 13 (54%) in segment IV. Mucinous cystic neoplasms were significantly larger than intraductal papillary neoplasms (median diameter: 110 vs 50 mm, P=0.008). In contrast to intraductal papillary neoplasms that were all histologically malignant, 26 mucinous cystic neoplasms (90%) were adenomas, 2 (7%) were borderline malignant, and 1 (3%) was a carcinoma in situ. Benign mucinous cystadenomas had the pure biliary immunophenotype, whereas gastrointestinal markers including cytokeratin 20 and mucin core proteins 2, 5AC, and 6 were more frequently expressed in borderline or malignant mucinous cystic neoplasms and biliary intraductal papillary neoplasms. There was no mortality in the patients with mucinous cystic neoplasm, whereas one patient with intraductal papillary neoplasm died of cancer. In conclusion, hepatic mucinous cystic neoplasms and biliary intraductal papillary neoplasms have different clinicopathological characteristics as evidenced by differences in the age and gender of patients, macroscopic appearance, immunophenotypes, and grades of malignancy

Id prodotto:

68905

Handle IRIS:

11562/430571

depositato il:

6 luglio 2012

ultima modifica:

25 novembre 2022

Citazione bibliografica:

Zen, Y; Pedica, Federica; Patcha, Vr; Capelli, Paola; Zamboni, Giuseppe; Casaril, Andrea; Quaglia, A; Nakanuma, Y; Heaton, N; Portmann, B., Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct «Modern Pathology» , vol. 24 , n. 8 , 2011 , pp. 1079-1089

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