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IN VITRO CHARACTERIZATION OF THE DIFFERENTIATION OF MENINGEAL STEM/PRECURSOR CELLS INTO THE OLIGODENDROCYTE LINEAGE  (2012)

Authors:
BERTON VALERIA; DECIMO ILARIA; BIFARI FRANCESCO; MALPELI GIORGIO; KRAMPERA MAURO; FUMAGALLI GUIDO
Title:
IN VITRO CHARACTERIZATION OF THE DIFFERENTIATION OF MENINGEAL STEM/PRECURSOR CELLS INTO THE OLIGODENDROCYTE LINEAGE
Year:
2012
Type of item:
Poster
Tipologia ANVUR:
Poster
Nations of authors:
ITALIA
Language:
Inglese
Format:
Elettronico
Congresso:
Summer School: Neural Stem Cells in Development and Disease
Place:
Levico Terme
Period:
4-8/09/2012
Page numbers:
0-0
Keyword:
NEURAL STEM CELLS, OLIGODENDROCYTE DIFFERENTIATION
Short description of contents:
In most diseases of the spinal cord, demyelination plays an important role in the generation and progression of the neurodegenerative lesion. Despite the fact that the spinal cord shows potential for regeneration of Schwann cells, this is limited and apparently insufficient for repair. Attempts to establish regenerative approaches by neural stem cell transplantation have been so far limited by lack of knowledge of the function of resident SCs and of adequate sources of cells. We have recently described that Leptomeninges of the spinal cord are a niche for neural stem cells (Decimo et al, 2011). These Leptomeningeal Stem Cells (LeSCs) are endowed with self-renewal properties and can differentiate into neurons and oligodendrocytes when stimulated with the appropriate factors. Considering that remyelinization may be a realistic and efficient goal for transplantation-based regenerative therapies of the spinal cord, we decided to define conditions for efficient and high-yield generation of precursor and differentiated cells of the oligodendrocyte lineage. In conclusion, we have established an efficient and reproducible method to generate large numbers of cells of oligodendrocyte-lineage at different and controlled levels of differentiation. Testing of remyelinization efficiency by different sets of cells will be performed in vitro and by transplantation experiments in vivo using animal models of traumatic lesion of the spinal cord and of multiple sclerosis.
Product ID:
76090
Handle IRIS:
11562/500362
Deposited On:
November 18, 2015
Last Modified:
November 2, 2016
Bibliographic citation:
BERTON VALERIA; DECIMO ILARIA; BIFARI FRANCESCO; MALPELI GIORGIO; KRAMPERA MAURO; FUMAGALLI GUIDO, IN VITRO CHARACTERIZATION OF THE DIFFERENTIATION OF MENINGEAL STEM/PRECURSOR CELLS INTO THE OLIGODENDROCYTE LINEAGE  in Summer School: Neural Stem Cells in Development and Disease Abstracts CDProceedings of "Summer School: Neural Stem Cells in Development and Disease" , Levico Terme , 4-8/09/2012 , 2012pp. 0-0

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Title Department Managers
Adult spinal cord meninges: a new source of neural stem cell for regenerative medicine Department Diagnostica e Sanità Pubblica Guido Francesco Fumagalli
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