Publications

Migration of meningeal cells in response to contusive spinal cord injury  (2012)

Authors:
BERTON VALERIA; BIFARI FRANCESCO; RODRIGUEZ FRANCISCO JAVIER; KRAMPERA MAURO; FUMAGALLI GUIDO; DECIMO ILARIA
Title:
Migration of meningeal cells in response to contusive spinal cord injury
Year:
2012
Type of item:
Abstract in Atti di convegno
Tipologia ANVUR:
Abstract in Atti di convegno
Nations of authors:
SPAGNA; ITALIA
Language:
Inglese
Format:
A Stampa
Congresso:
The Show of regeneration - Easy to see hard to foresee
Place:
Berlin
Period:
4-7/12/2012
Page numbers:
40-40
Keyword:
NEURAL STEM CELLS, SPINAL CORD INJURY, MIGRATION
Short description of contents:
Recently, we have characterized adult brain and spinal cord meninges and demonstrated that meninges contain nestin-positive cells, endowed with self-renewal and proliferative properties, and neural precursor doublecortin (DCX)-positive cells (Bifari et la 2009, Decimo et al 2011). Cells extracted from meninges can be expanded as neurospheres and induced to specifically differentiate in vitro into either functional neurons or mature oligodendrocytes. Strikingly, following contusive spinal cord injury (SCI), meningeal stem/precursor cells proliferate and increase in number, suggesting that they are activated by injury. In this study we ask whether activated menigneal stem/precursor cells migrate from meninges to parenchyma upon injury-induced activation. In order to trace the meningeal stem/precursor cells we transduced meningeal cells in vivo with a lentiviral GFP vector.We found that meningeal stem/precursor cells migrate to the lesion site, express neuronal markers and persist in this region until 1 month post injury. This results suggest that meningeal stem/precursor cells may have a role in the parenchymal regenerative potential following SCI.
Product ID:
76088
Handle IRIS:
11562/500363
Deposited On:
November 18, 2015
Last Modified:
November 2, 2016
Bibliographic citation:
BERTON VALERIA; BIFARI FRANCESCO; RODRIGUEZ FRANCISCO JAVIER; KRAMPERA MAURO; FUMAGALLI GUIDO; DECIMO ILARIA, Migration of meningeal cells in response to contusive spinal cord injury  in The Show of regeneration - Easy to see hard to foresee Abstracts BookProceedings of "The Show of regeneration - Easy to see hard to foresee" , Berlin , 4-7/12/2012 , 2012pp. 40-40

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Title Department Managers
Adult spinal cord meninges: a new source of neural stem cell for regenerative medicine Department Diagnostica e Sanità Pubblica Guido Francesco Fumagalli
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