Pubblicazioni

Autori:

Porcaro, Antonio Benito; De Luyk, Nicolo'; Corsi, Paolo; Sebben, Marco; Tafuri, Alessandro; Cacciamani, Giovanni; DE MARCHI, Davide; Tamanini, Irene; Inverardi, Davide; Brunelli, Matteo; Cerruto, Maria Angela; Salvagno, GIAN LUCA; Guidi, Gian Cesare; Artibani, Walter

Titolo:

Preoperative plasma levels of total testosterone associated with high grade pathology-detected prostate cancer: preliminary results of a prospective study in a contemporary cohort of patients

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Current urology

ISSN Rivista:

1661-7649

N° Volume:

10

Numero o Fascicolo:

2

Intervallo pagine:

72-80

Parole chiave:

hyptothalamus-pituitary-testis-prostate axis; prostate cancer; retropubic radical prostatectomy; robot assisted radical prostatectomy; testosterone

Breve descrizione dei contenuti:

OBJECTIVES: To investigate the associations, if any, between preoperative plasma levels of total testosterone (TT) and pathology Gleason score (pGS) in a contemporary cohort of prostate cancer (PCa) patients. MATERIALS AND METHODS: Between November 2014 and June 2015, plasma levels of TT were measured in 142 patients who underwent radical prostatectomy. Exclusion criteria were as follows: 5α-reductase inhibitors, LH-releasing hormone analogues, or testosterone replacement treatment. The entire cohort, assessed by continuous and categorical variables, was classified into two groups according to the pGS that included low-intermediate (pGS 6-7) and high grade (pGS > 7) cases. TT was evaluated as a continuous variable. RESULTS: The cohort included 128 cases. High grade PCa was detected in 28 (21.8%) patients. Median plasma levels of both TT and prostate specific antigen (PSA) were significantly higher in these cases. In the clinical multivariate model, independent and positive predictors of pGS > 7 were TT (p = 0.041; OR = 1.004), PSA (p = 0.006; OR = 1.191), and bGS > 6 (p = 0.004; OR = 5.0); that is, a single unit increase in TT plasma levels increases the odds of having high grade PCa by 4%. CONCLUSION: In a contemporary cohort of patients, preoperative plasma levels of TT directly and independently associated with high grade PCa. High baseline plasma levels of TT might have clinical applications for managing PCa. New and well designed prospective studies dealing with this subject are required.

Pagina Web:

https://doi.org/10.1159/000447155

Id prodotto:

98668

Handle IRIS:

11562/967600

ultima modifica:

11 novembre 2022

Citazione bibliografica:

Porcaro, Antonio Benito; De Luyk, Nicolo'; Corsi, Paolo; Sebben, Marco; Tafuri, Alessandro; Cacciamani, Giovanni; DE MARCHI, Davide; Tamanini, Irene; Inverardi, Davide; Brunelli, Matteo; Cerruto, Maria Angela; Salvagno, GIAN LUCA; Guidi, Gian Cesare; Artibani, Walter, Preoperative plasma levels of total testosterone associated with high grade pathology-detected prostate cancer: preliminary results of a prospective study in a contemporary cohort of patients «Current urology» , vol. 10 , n. 2 , 2017 , pp. 72-80

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