Pubblicazioni

Autori:

Galiè, Mirco; Boschi, Federico; Scambi, Ilaria; Merigo, Flavia; Marzola, Pasquina; Altabella, Luisa; Lavagnolo, Umberto; Sbarbati, Andrea; Spinelli, Antonello E.

Titolo:

Theranostic Role of (32)P-ATP as Radiopharmaceutical for the Induction of Massive Cell Death within Avascular Tumor Core

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

THERANOSTICS

ISSN Rivista:

1838-7640

N° Volume:

7

Numero o Fascicolo:

18

Intervallo pagine:

4399-4409

Parole chiave:

32P-ATP radiopharmaceutical; Cerenkov luminescence imaging; colorectal adenocarcinoma.; magnetic resonance imaging

Breve descrizione dei contenuti:

Drug inaccessibility to vast areas of the tumor parenchyma is amongst the major hurdles for conventional therapies. Treatment efficacy rapidly decreases with distance from vessels and most of the tumor cells survive therapy. Also, between subsequent cycles of treatment, spared cancer cells replace those killed near the vessels, improving their access to nutrients, boosting their proliferation rate, and thus enabling tumor repopulation. Because of their property of "acting at a distance," radioisotopes are believed to overcome the physical barrier of vascular inaccessibility. Methods: A novel molecular imaging tool called Cerenkov Luminescence Imaging (CLI) was employed for the detection of Cerenkov radiation emitted by beta particles, allowing in vivo tracking of beta-emitters. More precisely we investigated using a xenograft model of colon carcinoma the potential use of 32P-ATP as a novel theranostic radiopharmaceutical for tracing tumor lesions while simultaneously hampering their growth. Results: Our analyses demonstrated that 32P-ATP injected into tumor-bearing mice reaches tumor lesions and persists for days and weeks within the tumor parenchyma. Also, the high-penetrating beta particles of 32P-ATP exert a "cross-fire" effect that induces massive cell death throughout the entire tumor parenchyma including core regions. Conclusion: Our findings suggest 32P-ATP treatment as a potential approach to complement conventional therapies that fail to reach the tumor core and to prevent tumor repopulation.

Pagina Web:

https://doi.org/10.7150/thno.21403

Id prodotto:

99310

Handle IRIS:

11562/970033

ultima modifica:

28 marzo 2023

Citazione bibliografica:

Galiè, Mirco; Boschi, Federico; Scambi, Ilaria; Merigo, Flavia; Marzola, Pasquina; Altabella, Luisa; Lavagnolo, Umberto; Sbarbati, Andrea; Spinelli, Antonello E., Theranostic Role of (32)P-ATP as Radiopharmaceutical for the Induction of Massive Cell Death within Avascular Tumor Core «THERANOSTICS» , vol. 7 , n. 18 , 2017 , pp. 4399-4409

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