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A three-generation study on the association of tobacco smoking with asthma  (2018)

Authors:
Accordini, S; Calciano, L; Johannessen, A; Portas, L; Benediktsdóttir, B; Bertelsen, Rj; Bråbäck, L; Carsin, Ae; Dharmage, Sc; Dratva, J; Forsberg, B; Gomez Real, F; Heinrich, J; Holloway, Jw; Holm, M; Janson, C; Jögi, R; Leynaert, B; Malinovschi, A; Marcon, A; Martínez-Moratalla Rovira, J; Raherison, C; Sánchez-Ramos, Jl; Schlünssen, V; Bono, R; Corsico, Ag; Demoly, P; Dorado Arenas, S; Nowak, D; Pin, I; Weyler, J; Jarvis, D; Svanes, C
Title:
A three-generation study on the association of tobacco smoking with asthma
Year:
2018
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
Elettronico
Referee:
Name of journal:
International Journal of Epidemiology
ISSN of journal:
0300-5771
N° Volume:
47
Number or Folder:
4
Page numbers:
1106-1117
Keyword:
asthma, mothers’ smoking during pregnancy, grandmothers’ smoking during pregnancy, fathers’ smoking during puberty, multilevel mediation model, Ageing Lungs in European Cohorts (ALEC) Study
Short description of contents:
BACKGROUND: Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. METHODS: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. RESULTS: Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55). CONCLUSIONS: Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception. FUNDING: European Union (Horizon 2020, GA-633212).
Note:
Funding: European Union (EU) Horizon 2020 Research and Innovation Action, PHC-01-2014, ALEC, Grant Number P633212
Web page:
https://academic.oup.com/ije/advance-article/doi/10.1093/ije/dyy031/4925526
Product ID:
101598
Handle IRIS:
11562/976041
Last Modified:
January 31, 2019
Bibliographic citation:
Accordini, S; Calciano, L; Johannessen, A; Portas, L; Benediktsdóttir, B; Bertelsen, Rj; Bråbäck, L; Carsin, Ae; Dharmage, Sc; Dratva, J; Forsberg, B; Gomez Real, F; Heinrich, J; Holloway, Jw; Holm, M; Janson, C; Jögi, R; Leynaert, B; Malinovschi, A; Marcon, A; Martínez-Moratalla Rovira, J; Raherison, C; Sánchez-Ramos, Jl; Schlünssen, V; Bono, R; Corsico, Ag; Demoly, P; Dorado Arenas, S; Nowak, D; Pin, I; Weyler, J; Jarvis, D; Svanes, C, A three-generation study on the association of tobacco smoking with asthma «International Journal of Epidemiology» , vol. 47 , n. 42018pp. 1106-1117

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