Publications

Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study  (2018)

Authors:
Marcon, Alessandro; Locatelli, Francesca; Keidel, Dirk; B Beckmeyer-Borowko, Anna; Cerveri, Isa; C Dharmage, Shyamali; Fuertes, Elaine; Garcia-Aymerich, Judith; Heinrich, Joachim; Imboden, Medea; Janson, Christer; Johannessen, Ane; Leynaert, Bénédicte; Pascual Erquicia, Silvia; Pesce, Giancarlo; Schaffner, Emmanuel; Svanes, Cecilie; Urrutia, Isabel; Jarvis, Deborah; M Probst-Hensch, Nicole; Accordini, Simone
Title:
Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study
Year:
2018
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
Thorax
ISSN of journal:
0040-6376
N° Volume:
73
Number or Folder:
9
Page numbers:
825-832
Keyword:
Bronchial hyperreactivity; bronchial provocation tests; chronic obstructive pulmonary disease; longitudinal studies; lung function in epidemiology; smoking
Short description of contents:
Background It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk. Objective We studied prospectively whether airway responsiveness is associated with the risk of developing COPD. Methods We pooled data from two multicentre cohort studies that collected data from three time points using similar methods (European Community Respiratory Health Survey and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults). We classified subjects (median age 37 years, 1st–3rd quartiles: 29–44) by their level of airway responsiveness using quintiles of methacholine dose–response slope at the first examination (1991–1994). Then, we excluded subjects with airflow obstruction at the second examination (1999–2003) and analysed incidence of COPD (postbronchodilator FEV1/FVC below the lower limit of normal) at the third examination (2010–2014) as a function of responsiveness, adjusting for sex, age, education, body mass index, history of asthma, smoking, occupational exposures and indicators of airway calibre. Results We observed 108 new cases of COPD among 4205 subjects during a median time of 9 years. Compared with the least responsive group (incidence rate 0.6 per 1000/year), adjusted incidence rate ratios for COPD ranged from 1.79 (95% CI 0.52 to 6.13) to 8.91 (95% CI 3.67 to 21.66) for increasing airway responsiveness. Similar dose–response associations were observed between smokers and non-smokers, and stronger associations were found among subjects without a history of asthma or asthma-like symptoms. Conclusions Our study suggests that increased airway responsiveness is an independent risk factor for COPD. Further research should clarify whether early treatment in patients with high responsiveness can slow down disease progression.
Note:
Funding: European Union (EU) Horizon 2020 Research and Innovation Action, PHC-01-2014, ALEC, Grant Number P633212
Web page:
http://thorax.bmj.com/cgi/content/full/thoraxjnl-2017-211289
Product ID:
102572
Handle IRIS:
11562/979300
Last Modified:
December 4, 2019
Bibliographic citation:
Marcon, Alessandro; Locatelli, Francesca; Keidel, Dirk; B Beckmeyer-Borowko, Anna; Cerveri, Isa; C Dharmage, Shyamali; Fuertes, Elaine; Garcia-Aymerich, Judith; Heinrich, Joachim; Imboden, Medea; Janson, Christer; Johannessen, Ane; Leynaert, Bénédicte; Pascual Erquicia, Silvia; Pesce, Giancarlo; Schaffner, Emmanuel; Svanes, Cecilie; Urrutia, Isabel; Jarvis, Deborah; M Probst-Hensch, Nicole; Accordini, Simone, Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study «Thorax» , vol. 73 , n. 92018pp. 825-832

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