Ageing Lungs in European Cohorts (ALEC) Study

Data inizio
1 maggio 2015
Durata (mesi) 
Diagnostica e Sanità Pubblica
Responsabili (o referenti locali)
Accordini Simone
Parole chiave
lung function, cohorts, Horizon 2020

The ALEC Study will improve our understanding of risk factors for low lung function, respiratory disability and the development of chronic obstructive lung disease (COPD), by using information held within existing cohort studies (ALSPAC, ECRHS, NFBC, RHINESSA, SAPALDIA, TAHS). Even though COPD has long been viewed as a predominantly smoking-related disease, there is increasing awareness that lifestyle and environment contribute to disease even from very early in life, including before birth.

The ALEC Study is led by Professor Debbie Jarvis, from the National Heart and Lung Institute, Imperial College, London.

The ALEC Study has 7 Work Packages:
WP1 (Professor Debbie Jarvis, Imperial College London) - Management
WP2 (Professor Cecilie Svanes, University of Bergen) - Preconception and transgenerational risk factors
WP3 (Professor John Henderson, University of Bristol) - Lung function growth and submaximal lung function attainment in children
WP4 (Dr Judith Garcia Aymerich, CREAL Barcelona) - Lung function decline
WP5 (Professor Nicole Probst-Hensch, Swiss TPH Basel) - Change in DNA methylation and lung function
WP6 (Dr Cosetta Minelli, Imperial College London) - Integration and translation
WP7 (Professor Debbie Jarvis, Imperial College London) - Dissemination
Three work packages are for risk factor identification each concentrating on a particular phase of life: pre-conception and transgenerational (WP2), childhood (WP3) and adulthood (WP4). WP5 is responsible for generation of new data on change in DNA methylation (DNAm) from two cohorts (ECRHS and SAPALDIA), and for overall and targeted analyses on changes in DNAm with age, disease evolution and exposures to specific risk factors from all cohorts. WP6 is responsible for the integration and translation of findings into a predictive risk score for COPD. WP1 is related to study management and WP7 is related to dissemination. 

The ALEC Study is funded by the European Union's Horizon 2020 Research and Innovation programme under grant agreement No. 633212.

Enti finanziatori:

Commissione Europea
Finanziamento: assegnato e gestito dal Dipartimento
Programma: EUROPA - Progetti Europei

Partecipanti al progetto

Simone Accordini
Professore associato
Lucia Cazzoletti
Professore associato
Francesca Locatelli
Alessandro Marcon
Ricercatore a tempo determinato
Titolo Autori Anno
Atopy modifies the association between inhaled corticosteroid use and lung function decline in patients with asthma Marcon, Alessandro; Marchetti, Pierpaolo; Antó, Josep M; Cazzoletti, Lucia; Cerveri, Isa; Corsico, Angelo; Ferreira, Diogenes Seraphim; Garcia-Aymerich, Judith; Gislason, David; Heinrich, Joachim; Jõgi, Rain; Johannessen, Ane; Leynaert, Bénédicte; Malinovschi, Andrei; Pin, Isabelle; Probst-Hensch, Nicole; Weyler, Joost; Janson, Christer; Jarvis, Deborah; Accordini, Simone 2020
Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation? Johannessen, A; Lønnebotn, M; Calciano, L; Benediktsdóttir, B; Bertelsen, Rj; Bråbäck, L; Dharmage, S; Franklin, Ka; Gislason, T; Holm, M; Janson, C; Jarvis, D; Jõgi, R; Kim, Jl; Kirkeleit, J; Lodge, C; Malinovschi, A; Martinez-Moratalla, J; Nilsen, Rm; Pereira-Vega, A; Real, Fg; Schlünssen, V; Accordini, S; Svanes, C 2020
Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study Accordini, Simone; Calciano, Lucia; Marcon, Alessandro; Pesce, Giancarlo; M Antó, Josep; B Beckmeyer-Borowko, Anna; Carsin, Anne-Elie; Corsico, Angelo Guido; Imboden, Medea; Janson, Christer; Keidel, Dirk; Locatelli, Francesca; Svanes, Cecilie; GJ Burney, Peter; Jarvis, Deborah; M Probst-Hensch, Nicole; Minelli, Cosetta 2020
Bronchodilator reversibility in asthma and COPD: findings from three large population studies Janson, Christer; Malinovschi, Andrei; Amaral, Andre F S; Accordini, Simone; Bousquet, Jean; Buist, Sonia A; Canonica, Giorgio Walter; Dahlén, Barbro; Garcia-Aymerich, Judith; Gnatiuc, Louisa; Kowalski, Marek L; Patel, Jaymini; Tan, Wan; Torén, Kjell; Zuberbier, Torsten; Burney, Peter; Jarvis, Deborah 2019
Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS) Triebner, Kai; Accordini, Simone; Calciano, Lucia; Johannessen, Ane; Benediktsdóttir, Bryndís; Bifulco, Ersilia; Demoly, Pascal; Dharmage, Shyamali C; Franklin, Karl A; Garcia-Aymerich, Judith; Gullón Blanco, José Antonio; Heinrich, Joachim; Holm, Mathias; Jarvis, Debbie; Jõgi, Rain; Lindberg, Eva; Martínez-Moratalla, Jesús; Muniozguren Agirre, Nerea; Pin, Isabelle; Probst-Hensch, Nicole; Raherison, Chantal; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Svanes, Cecilie; Hustad, Steinar; Leynaert, Bénédicte; Gómez Real, Francisco 2019
Restrictive spirometry pattern is associated with low physical activity levels. A population based international study Carsin, Anne-Elie; Fuertes, Elaine; Schaffner, Emmanuel; Jarvis, Debbie; Antó, Josep M; Heinrich, Joachim; Bellisario, Valeria; Svanes, Cecilie; Keidel, Dirk; Imboden, Medea; Weyler, Joost; Nowak, Dennis; Martinez-Moratalla, Jesus; Gullón, José-Antonio; Sanchez Ramos, José Luis; Caviezel, Seraina; Beckmeyer-Borowko, Anna; Raherison, Chantal; Pin, Isabelle; Demoly, Pascal; Cerveri, Isa; Accordini, Simone; Gislason, Thorarinn; Toren, Kjell; Forsberg, Bertil; Janson, Christer; Jogi, Rain; Emtner, Margareta; Gómez Real, Francisco; Raza, Wasif; Leynaert, Bénédicte; Pascual, Silvia; Guerra, Stefano; Dharmage, Shyamali C; Probst-Hensch, Nicole; Garcia-Aymerich, Judith 2019
The role of C-reactive protein levels on the association of physical activity with lung function in adults Fuertes, Elaine; Carsin, Anne-Elie; Garcia-Larsen, Vanessa; Guerra, Stefano; Pin, Isabelle; Leynaert, Bénédicte; Accordini, Simone; Martinez-Moratalla, Jesús; Antó, Josep M; Urrutia, Isabel; Le Gouellec, Audrey; Heinrich, Joachim; Gislason, Thorarinn; Jõgi, Rain; Janson, Christer; Jarvis, Debbie; Garcia-Aymerich, Judith 2019
Time and age trends in smoking cessation in Europe Pesce, Giancarlo; Marcon, Alessandro; Calciano, Lucia; Perret, Jennifer L; Abramson, Michael J; Bono, Roberto; Bousquet, Jean; Fois, Alessandro G; Janson, Christer; Jarvis, Deborah; Jõgi, Rain; Leynaert, Bénédicte; Nowak, Dennis; Schlünssen, Vivi; Urrutia-Landa, Isabel; Verlato, Giuseppe; Villani, Simona; Zuberbier, Torsten; Minelli, Cosetta; Accordini, Simone 2019
Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study Marcon, Alessandro; Locatelli, Francesca; Keidel, Dirk; B Beckmeyer-Borowko, Anna; Cerveri, Isa; C Dharmage, Shyamali; Fuertes, Elaine; Garcia-Aymerich, Judith; Heinrich, Joachim; Imboden, Medea; Janson, Christer; Johannessen, Ane; Leynaert, Bénédicte; Pascual Erquicia, Silvia; Pesce, Giancarlo; Schaffner, Emmanuel; Svanes, Cecilie; Urrutia, Isabel; Jarvis, Deborah; M Probst-Hensch, Nicole; Accordini, Simone 2018
A three-generation study on the association of tobacco smoking with asthma Accordini, S; Calciano, L; Johannessen, A; Portas, L; Benediktsdóttir, B; Bertelsen, Rj; Bråbäck, L; Carsin, Ae; Dharmage, Sc; Dratva, J; Forsberg, B; Gomez Real, F; Heinrich, J; Holloway, Jw; Holm, M; Janson, C; Jögi, R; Leynaert, B; Malinovschi, A; Marcon, A; Martínez-Moratalla Rovira, J; Raherison, C; Sánchez-Ramos, Jl; Schlünssen, V; Bono, R; Corsico, Ag; Demoly, P; Dorado Arenas, S; Nowak, D; Pin, I; Weyler, J; Jarvis, D; Svanes, C 2018
Body silhouettes as a tool to reflect obesity in the past Lønnebotn, M; Svanes, C; Igland, J; Franklin, Ka; Accordini, S; Benediktsdóttir, B; Bentouhami, H; Blanco, Jag; Bono, R; Corsico, A; Demoly, P; Dharmage, S; Dorado Arenas, S; Garcia, J; Heinrich, J; Holm, M; Janson, C; Jarvis, D; Leynaert, B; Martinez-Moratalla, J; Nowak, D; Pin, I; Raherison-Semjen, C; Sánchez-Ramos, Jl; Schlünssen, V; Skulstad, Sm; Dratva, J; Gómez Real, F 2018
Leisure-time vigorous physical activity is associated with better lung function: the prospective ECRHS study Fuertes, Elaine; Carsin, Anne-Elie; Antó, Josep M; Bono, Roberto; Corsico, Angelo Guido; Demoly, Pascal; Gislason, Thorarinn; Gullón, José-Antonio; Janson, Christer; Jarvis, Deborah; Heinrich, Joachim; Holm, Mathias; Leynaert, Bénédicte; Marcon, Alessandro; Martinez-Moratalla, Jesús; Nowak, Dennis; Pascual Erquicia, Silvia; Probst-Hensch, Nicole M; Raherison, Chantal; Raza, Wasif; Gómez Real, Francisco; Russell, Melissa; Sánchez-Ramos, José Luis; Weyler, Joost; Garcia Aymerich, Judith 2018
Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study Fuertes, Elaine; Markevych, Iana; Jarvis, Deborah; Vienneau, Danielle; de Hoogh, Kees; Antó, Josep Maria; Bowatte, Gayan; Bono, Roberto; Corsico, Angelo G; Emtner, Margareta; Gislason, Thorarinn; Gullón, José Antonio; Heinrich, Joachim; Henderson, John; Holm, Mathias; Johannessen, Ane; Leynaert, Bénédicte; Marcon, Alessandro; Marchetti, Pierpaolo; Moratalla, Jesús Martínez; Pascual, Silvia; Probst-Hensch, Nicole; Sánchez-Ramos, José Luis; Siroux, Valerie; Sommar, Johan; Weyler, Joost; Kuenzli, Nino; Jacquemin, Bénédicte; Garcia-Aymerich, Judith 2018
Trends in smoking initiation in Europe over 40 years: A retrospective cohort study Marcon, Alessandro; Pesce, Giancarlo; Calciano, Lucia; Bellisario, Valeria; Dharmage, Shyamali C; Garcia-Aymerich, Judith; Gislasson, Thorarinn; Heinrich, Joachim; Holm, Mathias; Janson, Christer; Jarvis, Deborah; Leynaert, Bénédicte; Matheson, Melanie C; Pirina, Pietro; Svanes, Cecilie; Villani, Simona; Zuberbier, Torsten; Minelli, Cosetta; Accordini, Simone 2018