Pubblicazioni

In vitro characterization of the differentiation of meningeal Stem/precursor cells into the oligodendrocyte lineage  (2012)

Autori:
Berton, Valeria; Decimo, Ilaria; Bifari, Francesco; Malpeli, Giorgio; Krampera, Mauro; Fumagalli, Guido Francesco
Titolo:
In vitro characterization of the differentiation of meningeal Stem/precursor cells into the oligodendrocyte lineage
Anno:
2012
Tipologia prodotto:
Poster
Tipologia ANVUR:
Poster
Lingua:
Inglese
Formato:
A Stampa
Titolo del Convegno:
2nd meeting "Opportunity and challenges in the pharmacological modulation of adult neural stem cells"
Luogo:
Novara
Periodo:
14-15/12/2012
Intervallo pagine:
0-0
Parole chiave:
NEURAL STEM CELLS, OLIGODENDROCYTE DIFFERENTIATION
Breve descrizione dei contenuti:
In most diseases of the spinal cord, demyelination plays an important role in the generation and progression of the neurodegenerative lesion. Despite the fact that the spinal cord shows potential for regeneration, this is limited and apparently insufficient for repair and attempts to establish regenerative approaches by neural stem cell transplantation have been so far only partially successful. We have recently described that Leptomeninges of the spinal cord are a niche for neural stem cells (Decimo et al, 2011). These Leptomeningeal Stem Cells (LeSCs) are endowed with self-renewal properties and can differentiate into neurons and oligodendrocytes when stimulated with the appropriate factors. Considering that remyelinization may be a realistic and efficient goal for transplantation-based regenerative therapies of the spinal cord, we decided to define conditions for efficient and high-yield generation of precursor and differentiated cells of the oligodendrocyte lineage. In conclusion, we have established an efficient and reproducible method to generate large numbers of cells of oligodendrocyte-lineage at different and controlled levels of differentiation. Testing of remyelinization efficiency by different sets of cells will be performed in vitro and by transplantation experiments in vivo using animal models of traumatic lesion of the spinal cord and of multiple sclerosis.
Id prodotto:
76091
Handle IRIS:
11562/500364
depositato il:
4 febbraio 2013
ultima modifica:
14 novembre 2022
Citazione bibliografica:
Berton, Valeria; Decimo, Ilaria; Bifari, Francesco; Malpeli, Giorgio; Krampera, Mauro; Fumagalli, Guido Francesco, In vitro characterization of the differentiation of meningeal Stem/precursor cells into the oligodendrocyte lineage  in 2nd meeting "Opportunity and challenges in the pharmacological modulation of adult neural stem cells" Abstracts BookAtti di "2nd meeting "Opportunity and challenges in the pharmacological modulation of adult neural stem cells"" , Novara , 14-15/12/2012 , 2012pp. 0-0

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Progetti Collegati
Titolo Dipartimento Responsabili
Adult spinal cord meninges: a new source of neural stem cell for regenerative medicine Dipartimento Diagnostica e Sanità Pubblica Guido Francesco Fumagalli
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