Gruppi di ricerca

Laboratorio Chemioterapia

 

 
Research Topics
  • In vitro and in vivo efficacy of new antimicrobial drugs.
  • Pharmacokinetic-pharmacodynamic correlation of antimicrobial chemotherapeutic agents with in vivo experimental models
  • Pharmacokinetic characteristics of antibiotics and definition of degree of diffusion in extravascular compartment
  • Pharmacokinetic characteristics of antimicrobial drugs and definition of degree of diffusion in the gastrointestinal compartment
  • Intestinal microflora composition and modifications induced by administration of antimicrobial drugs or gastrointestinal pathology.
  • Probiotics
  • Evaluation of antibiotic diffusion in vivo using osteomyelitis animal model
  • Evaluation of in vivo efficacy of different drug delivery systems (PMMA) of antimicrobial drugs using experimental infection animal models
  • Determination of antibiotic elution in vitro from PMMA antibiotic loaded bone cement
  • Determination of degree of penetration of antibiotics and antifungals in interstitial fluid using the suction blister fluid method
  • Determination of the diffusion of antibiotics in prosthetic orthopaedic infections and in acute pancreatitis in man
  • Determination of tissue diffusion of antibiotics and antifungals with tissue homogenization techniques
  • ·         Microbiological assay of antibiotics in biological fluids and tissues
  • ·          
  • Determination of intestinal microflora by classical microbiological methods and enzymatic activity in animal experimental models
 

 

Attività

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