- Autori:
-
Marcon, Alessandro; Marchetti, Pierpaolo; Antó, Josep M; Cazzoletti, Lucia; Cerveri, Isa; Corsico, Angelo; Ferreira, Diogenes Seraphim; Garcia-Aymerich, Judith; Gislason, David; Heinrich, Joachim; Jõgi, Rain; Johannessen, Ane; Leynaert, Bénédicte; Malinovschi, Andrei; Pin, Isabelle; Probst-Hensch, Nicole; Weyler, Joost; Janson, Christer; Jarvis, Deborah; Accordini, Simone
- Titolo:
-
Atopy modifies the association between inhaled corticosteroid use and lung function decline in patients with asthma
- Anno:
-
2020
- Tipologia prodotto:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Lingua:
-
Inglese
- Formato:
-
A Stampa
- Referee:
-
Sì
- Nome rivista:
- JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE
- ISSN Rivista:
- 2213-2198
- N° Volume:
-
8
- Numero o Fascicolo:
-
3
- Intervallo pagine:
-
980-988
- Parole chiave:
-
Allergic sensitization; Asthma; Atopy; Cohort study; Epidemiology; IgE; Inhaled corticosteroids; Lung function decline; Precision medicine; Response to corticosteroids
- Breve descrizione dei contenuti:
- BACKGROUND: Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response to ICSs; however, studies on predictors of long-term response are few. OBJECTIVE: To assess whether allergic sensitization can modify the association between ICS use and lung function decline over 20 years in adult asthma. METHODS: We used data from the 3 clinical examinations of the European Community Respiratory Health Survey. We measured ICS use (no use, and use for <1.3, 1.3-8, and >8 years) and FEV1 decline among subjects with asthma over the 2 periods between consecutive examinations. We conducted a cohort study combining data of the 2 periods (906 observations from 745 subjects) to assess whether the association between ICS use and FEV1 decline was modified by allergic sensitization (IgE > 0.35 kU/L for any of house-dust mite, timothy grass, cat, or Cladosporium). RESULTS: FEV1 decline was similar for non-ICS users, as well as ICS users for less than 1.3 years, with and without allergic sensitization. However, among subjects on ICSs for a longer period, sensitization was associated with an attenuated decline (Pinteraction = .006): in the group treated for more than 8 years, FEV1 decline was on average 27 mL/y (95% CIBonferroni-adjusted, 11-42) lower for subjects with sensitization compared with nonsensitized subjects. CONCLUSIONS: Our study suggests that biomarkers of atopy can predict a more favorable long-term response to ICSs. Randomized controlled studies are needed to confirm these findings.
- Note:
- pii: S2213-2198(19)30914-6
- Id prodotto:
-
111017
- Handle IRIS:
-
11562/1002423
- ultima modifica:
-
8 novembre 2022
- Citazione bibliografica:
-
Marcon, Alessandro; Marchetti, Pierpaolo; Antó, Josep M; Cazzoletti, Lucia; Cerveri, Isa; Corsico, Angelo; Ferreira, Diogenes Seraphim; Garcia-Aymerich, Judith; Gislason, David; Heinrich, Joachim; Jõgi, Rain; Johannessen, Ane; Leynaert, Bénédicte; Malinovschi, Andrei; Pin, Isabelle; Probst-Hensch, Nicole; Weyler, Joost; Janson, Christer; Jarvis, Deborah; Accordini, Simone,
Atopy modifies the association between inhaled corticosteroid use and lung function decline in patients with asthma
«JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE»
, vol.
8
, n.
3
,
2020
,
pp. 980-988
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