Pubblicazioni

Autori:

Marcon, Alessandro; Marchetti, Pierpaolo; Antó, Josep M; Cazzoletti, Lucia; Cerveri, Isa; Corsico, Angelo; Ferreira, Diogenes Seraphim; Garcia-Aymerich, Judith; Gislason, David; Heinrich, Joachim; Jõgi, Rain; Johannessen, Ane; Leynaert, Bénédicte; Malinovschi, Andrei; Pin, Isabelle; Probst-Hensch, Nicole; Weyler, Joost; Janson, Christer; Jarvis, Deborah; Accordini, Simone

Titolo:

Atopy modifies the association between inhaled corticosteroid use and lung function decline in patients with asthma

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE

ISSN Rivista:

2213-2198

N° Volume:

8

Numero o Fascicolo:

3

Intervallo pagine:

980-988

Parole chiave:

Allergic sensitization; Asthma; Atopy; Cohort study; Epidemiology; IgE; Inhaled corticosteroids; Lung function decline; Precision medicine; Response to corticosteroids

Breve descrizione dei contenuti:

BACKGROUND: Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response to ICSs; however, studies on predictors of long-term response are few. OBJECTIVE: To assess whether allergic sensitization can modify the association between ICS use and lung function decline over 20 years in adult asthma. METHODS: We used data from the 3 clinical examinations of the European Community Respiratory Health Survey. We measured ICS use (no use, and use for <1.3, 1.3-8, and >8 years) and FEV1 decline among subjects with asthma over the 2 periods between consecutive examinations. We conducted a cohort study combining data of the 2 periods (906 observations from 745 subjects) to assess whether the association between ICS use and FEV1 decline was modified by allergic sensitization (IgE > 0.35 kU/L for any of house-dust mite, timothy grass, cat, or Cladosporium). RESULTS: FEV1 decline was similar for non-ICS users, as well as ICS users for less than 1.3 years, with and without allergic sensitization. However, among subjects on ICSs for a longer period, sensitization was associated with an attenuated decline (Pinteraction = .006): in the group treated for more than 8 years, FEV1 decline was on average 27 mL/y (95% CIBonferroni-adjusted, 11-42) lower for subjects with sensitization compared with nonsensitized subjects. CONCLUSIONS: Our study suggests that biomarkers of atopy can predict a more favorable long-term response to ICSs. Randomized controlled studies are needed to confirm these findings.

Note:

pii: S2213-2198(19)30914-6

Id prodotto:

111017

Handle IRIS:

11562/1002423

ultima modifica:

8 novembre 2022

Citazione bibliografica:

Marcon, Alessandro; Marchetti, Pierpaolo; Antó, Josep M; Cazzoletti, Lucia; Cerveri, Isa; Corsico, Angelo; Ferreira, Diogenes Seraphim; Garcia-Aymerich, Judith; Gislason, David; Heinrich, Joachim; Jõgi, Rain; Johannessen, Ane; Leynaert, Bénédicte; Malinovschi, Andrei; Pin, Isabelle; Probst-Hensch, Nicole; Weyler, Joost; Janson, Christer; Jarvis, Deborah; Accordini, Simone, Atopy modifies the association between inhaled corticosteroid use and lung function decline in patients with asthma «JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE» , vol. 8 , n. 3 , 2020 , pp. 980-988

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo