Pubblicazioni

Autori:

Accordini, Simone; Calciano, Lucia; Marcon, Alessandro; Pesce, Giancarlo; M Antó, Josep; B Beckmeyer-Borowko, Anna; Carsin, Anne-Elie; Corsico, Angelo Guido; Imboden, Medea; Janson, Christer; Keidel, Dirk; Locatelli, Francesca; Svanes, Cecilie; GJ Burney, Peter; Jarvis, Deborah; M Probst-Hensch, Nicole; Minelli, Cosetta

Titolo:

Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

SCIENTIFIC REPORTS

ISSN Rivista:

2045-2322

N° Volume:

10

Numero o Fascicolo:

1

Intervallo pagine:

1-9

Parole chiave:

Ageing Lungs in European Cohorts (ALEC) Study, airflow obstruction, cohort study, European Community Respiratory Health Survey (ECRHS), incidence, Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), tobacco smoking, trend

Breve descrizione dei contenuti:

Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this information to estimate the incidence of post-bronchodilator AO (AOpost-BD), which is the primary characteristic of COPD. AO incidence was 4.4 (95%CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males; 12, females), AO incidence significantly increased with ageing in men only [incidence rate ratio (IRR), 1-year increase: 1.05 (1.03-1.07)]. A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increase: 1.03 (1.02-1.04)] and females [1.03 (1.02-1.05)]. The positive predictive value of AO for AOpost-BD was 59.1% (52.0-66.2%) in men and 42.6% (35.1-50.1%) in women. AOpost-BD incidence was 2.6 (1.7-3.4) male and 1.6 (1.0-2.2) female cases/1,000/year. AO incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers was strongly related to cumulative tobacco exposure. AOpost-BD incidence is expected to be half of AO incidence.

Pagina Web:

https://rdcu.be/b2cY2

Id prodotto:

113083

Handle IRIS:

11562/1012426

ultima modifica:

25 novembre 2022

Citazione bibliografica:

Accordini, Simone; Calciano, Lucia; Marcon, Alessandro; Pesce, Giancarlo; M Antó, Josep; B Beckmeyer-Borowko, Anna; Carsin, Anne-Elie; Corsico, Angelo Guido; Imboden, Medea; Janson, Christer; Keidel, Dirk; Locatelli, Francesca; Svanes, Cecilie; GJ Burney, Peter; Jarvis, Deborah; M Probst-Hensch, Nicole; Minelli, Cosetta, Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study «SCIENTIFIC REPORTS» , vol. 10 , n. 1 , 2020 , pp. 1-9

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