Pubblicazioni

Autori:

Plebani, Mario; Padoan, Andrea; Fedeli, Ugo; Schievano, Elena; Vecchiato, Elena; Lippi, Giuseppe; Lo Cascio, Giuliana; Porru, Stefano; Palù, Giorgio

Titolo:

SARS-CoV-2 serosurvey in health care workers of the Veneto Region

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

CLINICAL CHEMISTRY AND LABORATORY MEDICINE

ISSN Rivista:

1437-4331

N° Volume:

58

Numero o Fascicolo:

12

Intervallo pagine:

2107-2111

Parole chiave:

COVID-19, SARS-CoV-2 antibody, health care workers, seroprevalence

Breve descrizione dei contenuti:

Objectives The ongoing outbreak of coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses formidable challenges to all health care systems. Serological assays may be used for improving disease management when appropriately applied, for investigating the antibody responses mounted against SARS-CoV-2 infection and for assessing its real prevalence. Although testing the whole population is impractical, well-designed serosurveys in selected subpopulations in specific risk groups may provide valuable information. We evaluated the prevalence of SARS-CoV-2 infection in health care workers (HCW) who underwent molecular testing with reverse transcription real-time polymerase chain reaction (rRT-PCR) in the main hospitals of the Veneto Region of Italy by measuring specific antibodies (Abs). Methods Both immunoglobulin (Ig)M and IgG antibodies against SARS-Cov-2 S-antigen and N-protein were measured using a validated chemiluminescent analytical system (CLIA) called Maglumi™ 2000 Plus (New Industries Biomedical Engineering Co., Ltd [Snibe], Shenzhen, China). Results A total of 8,285 HCW were tested. SARS-CoV-2 specific antibodies (IgM, IgG or both) were detectable in 378 cases (4.6%, 95% CI 4.1-5.0%). Seroconversion was observed in 4.4% of women vs. 5.0% of men, but this difference was not significant. Although detectable antibodies were found in all HCW who developed severe COVID-19 infection (100%), lower seropositivity was found in mild disease (83%) and the lowest prevalence (58%) was observed in asymptomatic subjects. Conclusions Seroprevalence surveys are of utmost importance for understanding the rate of population that has already developed antibodies against SARS-CoV-2. The present study defined precisely the circulation of SARS-CoV-2 in a cohort of HCW in the Veneto Region, with its prevalence (4.6%) reflecting a relatively low circulation. Symptomatic individuals or those hospitalized for medical care were 100% antibody positive, whilst Abs were only detectable in 58% of asymptomatic carriers.

Pagina Web:

https://www.degruyter.com/view/journals/cclm/58/12/article-p2107.xml

Id prodotto:

115887

Handle IRIS:

11562/1023559

ultima modifica:

28 novembre 2022

Citazione bibliografica:

Plebani, Mario; Padoan, Andrea; Fedeli, Ugo; Schievano, Elena; Vecchiato, Elena; Lippi, Giuseppe; Lo Cascio, Giuliana; Porru, Stefano; Palù, Giorgio, SARS-CoV-2 serosurvey in health care workers of the Veneto Region «CLINICAL CHEMISTRY AND LABORATORY MEDICINE» , vol. 58 , n. 12 , 2020 , pp. 2107-2111

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