Pubblicazioni

Autori:

Martinelli, Nicola; Rigoni, Anna Maria; De Marchi, Sergio; Osti, Nicola; Donini, Martino; Montagnana, Martina; Castagna, Annalisa; Pattini, Patrizia; Udali, Silvia; De Franceschi, Lucia; Tinazzi, Elisa; Mazzi, Filippo; Moruzzi, Sara; Argentino, Giuseppe; Delfino, Lorenzo; Sartori, Giulia; Azzini, Anna Maria; Tacconelli, Evelina; Van Dreden, Patrick; Lippi, Giuseppe; Girelli, Domenico; Olivieri, Oliviero; Friso, Simonetta; Pizzolo, Francesca

Titolo:

High Plasma Levels of Activated Factor VII-Antithrombin Complex Point to Increased Tissue Factor Expression in Patients with SARS-CoV-2 Pneumonia: A Potential Link with COVID-19 Prothrombotic Diathesis

Anno:

2022

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

DIAGNOSTICS

ISSN Rivista:

2075-4418

N° Volume:

12

Numero o Fascicolo:

11

Intervallo pagine:

1-12

Parole chiave:

activated factor VII-antithrombin (FVIIa-AT); coagulation; coronavirus disease 2019 (COVID-19); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); tissue factor (TF)

Breve descrizione dei contenuti:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of coronavirus disease 2019 (COVID-19), in which coagulation abnormalities and endothelial dysfunction play a key pathogenic role. Tissue factor (TF) expression is triggered by endothelial dysfunction. Activated factor VII-antithrombin (FVIIa-AT) complex reflects indirectly FVIIa-TF interaction and has been proposed as a potential biomarker of prothrombotic diathesis. FVIIa-AT plasma concentration was measured in 40 patients (30 males and 10 females; 64.8 ± 12.3 years) admitted with SARS-CoV-2 pneumonia during the first pandemic wave in Italy. Two sex- and age-matched cohorts without COVID-19, with or without signs of systemic inflammation, were used to compare FVIIa-AT data. The FVIIa-AT plasma levels in COVID-19 patients were higher than those in non-COVID-19 subjects, either with or without inflammation, while no difference was observed among non-COVID-19 subjects. The association between COVID-19 and FVIIa-AT levels remained significant after adjustment for sex, age, C-reactive protein, renal function, fibrinogen, prothrombin time and activated partial thromboplastin time. Our results indicate that SARS-CoV-2 infection, at least during the first pandemic wave, was characterized by high FVIIa-AT levels, which may suggest an enhanced FVIIa-TF interaction in COVID-19, potentially consistent with SARS-CoV-2-induced endotheliopathy.

Id prodotto:

130330

Handle IRIS:

11562/1079509

ultima modifica:

31 marzo 2023

Citazione bibliografica:

Martinelli, Nicola; Rigoni, Anna Maria; De Marchi, Sergio; Osti, Nicola; Donini, Martino; Montagnana, Martina; Castagna, Annalisa; Pattini, Patrizia; Udali, Silvia; De Franceschi, Lucia; Tinazzi, Elisa; Mazzi, Filippo; Moruzzi, Sara; Argentino, Giuseppe; Delfino, Lorenzo; Sartori, Giulia; Azzini, Anna Maria; Tacconelli, Evelina; Van Dreden, Patrick; Lippi, Giuseppe; Girelli, Domenico; Olivieri, Oliviero; Friso, Simonetta; Pizzolo, Francesca, High Plasma Levels of Activated Factor VII-Antithrombin Complex Point to Increased Tissue Factor Expression in Patients with SARS-CoV-2 Pneumonia: A Potential Link with COVID-19 Prothrombotic Diathesis «DIAGNOSTICS» , vol. 12 , n. 11 , 2022 , pp. 1-12

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