Pubblicazioni

Autori:

Bontempi, Pietro; Rozzanigo, Umberto; Marangoni, Sabrina; Fogazzi, Elena; Ravanelli, Daniele; Cazzoletti, Lucia; Giometto, Bruno; Farace, Paolo

Titolo:

Non-lesional white matter in relapsing-remitting multiple sclerosis assessed by multicomponent T2 relaxation

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

BRAIN AND BEHAVIOR

ISSN Rivista:

2162-3279

N° Volume:

13

Numero o Fascicolo:

12

Intervallo pagine:

1-9

Parole chiave:

Myelin Water Imaging; T2 relaxometry; lesion segmentation; multiple sclerosis

Breve descrizione dei contenuti:

Introduction: The purpose of the study is to investigate, by T2 relaxation, non-lesional white matter (WM) in relapsing-remitting (RR) multiple sclerosis (MS). Methods: Twenty stable RR MS patients underwent 1.5T Magnetic Resonance Imaging (MRI) with 3D Fluid-Attenuated Inversion-Recovery (FLAIR), 3D-T1-weighted, and T2-relaxation multi-echo sequences. The Lesion Segmentation Tool processed FLAIR images to identify focal lesions (FLs), whereas T1 images were segmented to identify WM and FL sub-volumes with T1 hypo-intensity. Non-lesional WM was obtained as the segmented WM, excluding FL volumes. The multi-echo sequence allowed decomposition into myelin water, intra-extracellular water, and free water (Fw), which were evaluated on the segmented non-lesional WM. Correlation analysis was performed between the non-lesional WM relaxation parameters and Expanded Disability Status Scale (EDSS), disease duration, patient age, and T1 hypo-intense FL volumes. Results: The T1 hypo-intense FL volumes correlated with EDSS. On the non-lesional WM, the median Fw correlated with EDSS, disease duration, age, and T1 hypo-intense FL volumes. Bivariate EDSS correlation of FL volumes and WM T2-relaxation parameters did not improve significance. Conclusion: T2 relaxation allowed identifying subtle WM alterations, which significantly correlated with EDSS, disease duration, and age but do not seem to be EDSS-predictors independent from FL sub-volumes in stable RR patients. Particularly, the increase in the Fw component is suggestive of an uninvestigated prodromal phenomenon in brain degeneration.

Note:

Epub 2023 Dec 2

Id prodotto:

136530

Handle IRIS:

11562/1115390

ultima modifica:

23 dicembre 2023

Citazione bibliografica:

Bontempi, Pietro; Rozzanigo, Umberto; Marangoni, Sabrina; Fogazzi, Elena; Ravanelli, Daniele; Cazzoletti, Lucia; Giometto, Bruno; Farace, Paolo, Non-lesional white matter in relapsing-remitting multiple sclerosis assessed by multicomponent T2 relaxation «BRAIN AND BEHAVIOR» , vol. 13 , n. 12 , 2023 , pp. 1-9

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo