Pubblicazioni

Autori:

Margalit, Ili; Kunwar, Digbijay; Gadot, Chen; Meroi, Marco; Scardellato, Rebecca; Zamir, Amber; Koutsolioutsou, Anastasia; Goldberg, Elad; Righi, Elda; Yahav, Dafna

Titolo:

Clinical impact of active screening cultures for carbapenem-resistant Acinetobacter baumannii: A systematic review and meta-analysis

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

AMERICAN JOURNAL OF INFECTION CONTROL

ISSN Rivista:

0196-6553

N° Volume:

52

Numero o Fascicolo:

12

Intervallo pagine:

1351-1358

Parole chiave:

Hospital epidemiology; Infection control; Multidrug resistance; Sepsis

Breve descrizione dei contenuti:

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a significant healthcare-associated infection carrying substantial mortality. We aimed to assess the clinical impact of active screening cultures for CRAB. Methods: A systematic review and meta-analysis, aiming to answer two questions: 1. Does screening vs no screening improve clinical outcomes? 2. Does positive screening ("CRAB carrier") predict CRAB infections? We searched MEDLINE, Cochrane library, Web of Science, and conferences, until January 2024, comparative studies reporting clinical outcomes (mortality, invasive CRAB infections). Results: Of 5,407 screened publications, 9 studies (10,865 individuals) were included for study question #2. Invasive CRAB infection rate was significantly higher among CRAB carriers (odds ratio [OR] 11.14, 95% confidence interval [CI] 4.95-25.05, with substantial heterogeneity stemming from size rather than direction of the effect). Negative predictive value (NPV) of non-carriage for invasive infection was 97%. CRAB bloodstream infections rate was significantly higher among carriers (OR 16.23, 95% CI 2.9-110.08). No significant difference was demonstrated between the two groups CRAB ventilator-associated pneumonia, length of stay, and mortality. Only one study reported outcomes for the screening vs no screening (study question #1). Conclusions: Data to support active CRAB screening are scarce regarding its clinical benefit for patients. Positively screened patients are at significantly higher risk for invasive CRAB infections, with high NPV for non-carriage. This did not translate to reduced mortality.

Note:

Epub 2024 Jun 25

Id prodotto:

140362

Handle IRIS:

11562/1130008

ultima modifica:

8 dicembre 2024

Citazione bibliografica:

Margalit, Ili; Kunwar, Digbijay; Gadot, Chen; Meroi, Marco; Scardellato, Rebecca; Zamir, Amber; Koutsolioutsou, Anastasia; Goldberg, Elad; Righi, Elda; Yahav, Dafna, Clinical impact of active screening cultures for carbapenem-resistant Acinetobacter baumannii: A systematic review and meta-analysis «AMERICAN JOURNAL OF INFECTION CONTROL» , vol. 52 , n. 12 , 2024 , pp. 1351-1358

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo