Pubblicazioni

Autori:

Piva, Alessandro; Benvegnù, Giulia; Negri, Stefano; Commisso, Mauro; Ceccato, Sofia; Avesani, Linda; Guzzo, Flavia; Chiamulera, Cristiano

Titolo:

Whole Plant Extracts for Neurocognitive Disorders: A Narrative Review of Neuropsychological and Preclinical Studies

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

NUTRIENTS

ISSN Rivista:

2072-6643

N° Volume:

16

Numero o Fascicolo:

18

Intervallo pagine:

1-32

Parole chiave:

bioactive phytochemicals; cognitive functions; humans; rodents; neuropsychological tests; plant extracts

Breve descrizione dei contenuti:

The incidence of neurodegenerative disorders like Alzheimer's or Parkinson's Disease, characterized by a progressive cognitive decline, is rising worldwide. Despite the considerable efforts to unveil the neuropsychological bases of these diseases, there is still an unmet medical need for effective therapies against cognitive deficits. In recent years, increasing laboratory evidence indicates the potential of phytotherapy as an integrative aid to improve cognitive functions. In this review, we describe the data of plant whole extracts or single compounds' efficacy on validated preclinical models and neuropsychological tests, aiming to correlate brain mechanisms underlying rodent behavioral responses to human findings. After a search of the literature, the overview was limited to the following plants: Dioscorea batatas, Ginkgo biloba, Melissa officinalis, Nigella sativa, Olea europaea, Panax ginseng, Punica granatum, and Vitis vinifera. Results showed significant improvements in different cognitive functions, such as learning and memory or visuospatial abilities, in both humans and rodents. However, despite promising laboratory evidence, clinical translation has been dampened by a limited pharmacological characterization of the single bioactive components of the herbal products. Depicting the contribution of the single phytochemicals to the phytocomplex's pharmacological efficacy could enable the comprehension of their potential synergistic activity, leading to phytotherapy inclusion in the existing therapeutic package against cognitive decline.

Id prodotto:

141305

Handle IRIS:

11562/1139550

ultima modifica:

4 dicembre 2024

Citazione bibliografica:

Piva, Alessandro; Benvegnù, Giulia; Negri, Stefano; Commisso, Mauro; Ceccato, Sofia; Avesani, Linda; Guzzo, Flavia; Chiamulera, Cristiano, Whole Plant Extracts for Neurocognitive Disorders: A Narrative Review of Neuropsychological and Preclinical Studies «NUTRIENTS» , vol. 16 , n. 18 , 2024 , pp. 1-32

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