Pubblicazioni

Autori:

Enya, Arconada Nuin; Tuba, Vilken; Basil Britto, Xavier; Joachim, Doua; Brian, Morrow; Jeroen, Geurtsen; Oscar, Go; Bart, Spiessens; Michal, Sarnecki; Jan, Poolman; Marc, Bonten; Miquel, Ekkelenkamp; Christine, Lammens; Herman, Goossens; Youri, Glupczynski; Sandra, Van Puyvelde; Consortium/EXPECT Study Group: Gert Leten, COMBACTE-NET; Van Mieghem, Sofie; Violette, Madison; Munshi, Sonal; Aitabi, Moussa; Azzini, Anna Maria; Righi, Elda; Salerno, NICOLA DUCCIO; LO CASCIO, Giuliana; Cremonini, Eleonora; Pascual, Álvaro; Espíndola, Reinaldo; Palomo, Virginia; Barraud, Olivier; V Walker, Sarah; Akai, Naomi; Kimura, Risa; Lakatos, Louis; De Blacam, Killian; Thaden, Joshua; Ruffin, Felicia; Dagher, Michael

Titolo:

A microbiological and genomic perspective of globally collected Escherichia coli from adults hospitalized with invasive E. coli disease

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Journal of Antimicrobial Chemotherapy

ISSN Rivista:

0305-7453

N° Volume:

79

Numero o Fascicolo:

9

Intervallo pagine:

2142-2151

Parole chiave:

ampicillin; aztreonam; cefazolin; cefepime; ceftazidime; ceftriaxone; cotrimoxazole; genomic DNA; gentamicin; tetracycline derivative; tobramycin

Breve descrizione dei contenuti:

Objectives Escherichia coli can cause infections in the urinary tract and in normally sterile body sites leading to invasive E. coli disease (IED), including bacteraemia and sepsis, with older populations at increased risk. We aimed to estimate the theoretical coverage rate by the ExPEC4V and 9V vaccine candidates. In addition, we aimed at better understanding the diversity of E. coli isolates, including their genetic and phenotypic antimicrobial resistance (AMR), sequence types (STs), O-serotypes and the bacterial population structure.Methods Blood and urine culture E. coli isolates (n = 304) were collected from hospitalized patients >= 60 years (n = 238) with IED during a multicentric, observational study across three continents. All isolates were tested for antimicrobial susceptibility, O-serotyped, whole-genome sequenced and bioinformatically analysed.Results A large diversity of STs and of O-serotypes were identified across all centres, with O25b-ST131, O6-ST73 and O1-ST95 being the most prevalent types. A total of 45.4% and 64.7% of all isolates were found to have an O-serotype covered by the ExPEC4V and ExPEC9V vaccine candidates, respectively. The overall frequency of MDR was 37.4% and ST131 was predominant among MDR isolates. Low in-patient genetic variability was observed in cases where multiple isolates were collected from the same patient.Conclusions Our results highlight the predominance of MDR O25b-ST131 E. coli isolates across diverse geographic areas. These findings provide further baseline data on the theoretical coverage of novel vaccines targeting E. coli associated with IED in older adults and their associated AMR levels.

Id prodotto:

142631

Handle IRIS:

11562/1145346

ultima modifica:

23 novembre 2024

Citazione bibliografica:

Enya, Arconada Nuin; Tuba, Vilken; Basil Britto, Xavier; Joachim, Doua; Brian, Morrow; Jeroen, Geurtsen; Oscar, Go; Bart, Spiessens; Michal, Sarnecki; Jan, Poolman; Marc, Bonten; Miquel, Ekkelenkamp; Christine, Lammens; Herman, Goossens; Youri, Glupczynski; Sandra, Van Puyvelde; Consortium/EXPECT Study Group: Gert Leten, COMBACTE-NET; Van Mieghem, Sofie; Violette, Madison; Munshi, Sonal; Aitabi, Moussa; Azzini, Anna Maria; Righi, Elda; Salerno, NICOLA DUCCIO; LO CASCIO, Giuliana; Cremonini, Eleonora; Pascual, Álvaro; Espíndola, Reinaldo; Palomo, Virginia; Barraud, Olivier; V Walker, Sarah; Akai, Naomi; Kimura, Risa; Lakatos, Louis; De Blacam, Killian; Thaden, Joshua; Ruffin, Felicia; Dagher, Michael, A microbiological and genomic perspective of globally collected Escherichia coli from adults hospitalized with invasive E. coli disease «Journal of Antimicrobial Chemotherapy» , vol. 79 , n. 9 , 2024 , pp. 2142-2151

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo