Pubblicazioni

Autori:

Augello, Matteo; Bono, Valeria; Rovito, Roberta; Tavelli, Alessandro; Santoro, Andrea; Tincati, Camilla; Vergori, Alessandra; Azzini, Anna Maria; Righi, Elda; Spiteri, Gianluca; Porru, Stefano; Meschi, Silvia; Notari, Stefania; Maggi, Fabrizio; Antinori, Andrea; Tacconelli, Evelina; d'Arminio Monforte, Antonella; Marchetti, Giulia; VaxICONA-ORCHESTRA Study, Group

Titolo:

Long-term immune responses to SARS-CoV-2 Omicron BA.4/5 mRNA booster in people living with HIV

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

COMMUNICATIONS MEDICINE

ISSN Rivista:

2730-664X

N° Volume:

5

Numero o Fascicolo:

1

Intervallo pagine:

1-15

Parole chiave:

COVID-19 VACCINE, BIVALENT, PREDICT, ANTIBODIES

Breve descrizione dei contenuti:

Background: Variant-adapted vaccines are recommended in vulnerable populations to address the waning immunity and the emergence of immune-escaping SARS-CoV-2 variants, yet data about immune responses to such vaccines in people living with HIV (PLWH) are limited. We therefore aimed to assess long-term immune responses to an original-BA.4/5 mRNA booster in this population. Methods: In this prospective longitudinal study, PLWH receiving either an original-BA.4/5 bivalent booster or an original monovalent booster and HIV-negative healthcare workers (HCWs) receiving a bivalent booster were enrolled and sampled before (T0), 1 month (T1), and 4-9 months (T2) after the vaccine administration. SARS-CoV-2-specific T and B cells, RBD-binding antibodies, and RBD-blocking antibodies against both wild type (WT) and omicron BA.4/5 virus were determined. Results: The bivalent booster is able to transiently increase both humoral and polyfunctional T cell responses in PLWH, with humoral responses comparable to those observed in HCWs. While T cell responses are cross-reactive against viral variants and stable over time, humoral immunity is imprinted to the ancestral virus and wanes quickly. Furthermore, whilst previous SARS-CoV-2 infection does not affect the trajectory of vaccine-elicited immune responses, markers of HIV-related T cell dysfunction are associated with lower antibody peak responses and higher antibody waning. Lastly, the bivalent booster was superior to the monovalent one in inducing BA.4/5-reactive RBD-blocking antibodies. Conclusions: The original-BA.4/5 bivalent booster is highly immunogenic in PLWH and superior to the monovalent one in inducing humoral responses against the BA.4/5 virus, although HIV-related T cell dysfunction markers are associated with blunted and less durable antibody immunity.

Id prodotto:

144932

Handle IRIS:

11562/1158827

ultima modifica:

17 aprile 2025

Citazione bibliografica:

Augello, Matteo; Bono, Valeria; Rovito, Roberta; Tavelli, Alessandro; Santoro, Andrea; Tincati, Camilla; Vergori, Alessandra; Azzini, Anna Maria; Righi, Elda; Spiteri, Gianluca; Porru, Stefano; Meschi, Silvia; Notari, Stefania; Maggi, Fabrizio; Antinori, Andrea; Tacconelli, Evelina; d'Arminio Monforte, Antonella; Marchetti, Giulia; VaxICONA-ORCHESTRA Study, Group, Long-term immune responses to SARS-CoV-2 Omicron BA.4/5 mRNA booster in people living with HIV «COMMUNICATIONS MEDICINE» , vol. 5 , n. 1 , 2025 , pp. 1-15

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo