Pubblicazioni

Autori:

Luchini, Claudio; Franzina, Carlotta; Caldart, Federico; De Pretis, Nicolò; Crestani, Manola; Donadelli, Massimo; Mattiolo, Paola; Fiore, Alessandra; Danzi, Federica; De Robertis, Riccardo; Bevere, Michele; Baldan, Roberto; Tommasi, Laura; Vianini, Nicolò; Bernardi, Paolo; Galiè, Mirco; Pea, Antonio; Ciccocioppo, Rachele; D'Onofrio, Mirko; Salvia, Roberto; Verbeke, Caroline; Sbarbati, Andrea; Scarpa, Aldo; Veronese, Nicola; Frulloni, Luca

Titolo:

Fatty pancreas disease: an integrated study on frozen tissues shows distinct compartments of inter/intra-lobular, intra-acinar, and intra-islet fat deposition

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

Laboratory Investigation

ISSN Rivista:

0023-6837

N° Volume:

105

Numero o Fascicolo:

11

Intervallo pagine:

1-8

Parole chiave:

FPD; Fatty pancreas; Oil Red O; pancreatic metabolic disease; pancreatic steatosis

Breve descrizione dei contenuti:

: Obesity-related diseases and perturbations of fat metabolism represent some of the most common health challenges. In this complex scenario, recent evidence has pointed to the emergence of a condition related to fat accumulation in the pancreas, which is generally referred to as fatty pancreas disease. This study aims to clarify the different compartments of intra-pancreatic fat deposition. The study cohort is represented by 100 patients who underwent pancreatic surgical resection. The pancreatic neck margin was analyzed with hematoxylin-eosin for evaluating tissue composition and with Oil Red O, a fat-specific histochemical staining highlighting lipid droplets as red signals, for evaluating the presence of intracellular fat. Two cases were also analyzed with electron microscopy as cross-sectional validation. Regarding tissue composition, the most prevalent component was normal pancreatic parenchyma (mean value: 71.8%), followed by fibrosis (17.3%) and inter/intra-lobular fat (10.9%). Regarding intracellular fat deposition, Oil Red O-positive intracytoplasmic lipid droplets were present in most patients. The tissue areas with the highest levels of fat deposition were Langerhans' islets, with neuroendocrine/insular cells showing more commonly a diffuse pattern of fat accumulation (>75% of cells). Electron microscopy confirmed the presence of intracytoplasmic lipid vacuoles in neuroendocrine/insular cells. Our findings showed the presence of different compartments of intra-pancreatic fat deposition, both in terms of tissue composition and intracellular compartmentalization. Understanding the mechanisms of fat deposition in the pancreas is crucial towards improving the general knowledge on fatty pancreas disease, also opening new perspectives for the study of lipid metabolism and the treatment of fat-related diseases.

Id prodotto:

146982

Handle IRIS:

11562/1168807

ultima modifica:

13 settembre 2025

Citazione bibliografica:

Luchini, Claudio; Franzina, Carlotta; Caldart, Federico; De Pretis, Nicolò; Crestani, Manola; Donadelli, Massimo; Mattiolo, Paola; Fiore, Alessandra; Danzi, Federica; De Robertis, Riccardo; Bevere, Michele; Baldan, Roberto; Tommasi, Laura; Vianini, Nicolò; Bernardi, Paolo; Galiè, Mirco; Pea, Antonio; Ciccocioppo, Rachele; D'Onofrio, Mirko; Salvia, Roberto; Verbeke, Caroline; Sbarbati, Andrea; Scarpa, Aldo; Veronese, Nicola; Frulloni, Luca, Fatty pancreas disease: an integrated study on frozen tissues shows distinct compartments of inter/intra-lobular, intra-acinar, and intra-islet fat deposition «Laboratory Investigation» , vol. 105 , n. 11 , 2025 , pp. 1-8

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