Pubblicazioni

Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche  (2009)

Autori:
Bifari F.; Decimo I.; Chiamulera C.; Bersan E.; Malpeli G.; Johansson J.; Lisi V.; Bonetti B.; Fumagalli G.; Pizzolo G.; Krampera M.
Titolo:
Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche
Anno:
2009
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
A Stampa
Referee:
Nome rivista:
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
ISSN Rivista:
1582-1838
N° Volume:
13
Numero o Fascicolo:
9B
Intervallo pagine:
3195-3208
Parole chiave:
neural stem cells; leptomeninges; stem cell niche; neuronal differentiation
Breve descrizione dei contenuti:
Abstract Stem cells capable of generating neural differentiated cells are recognized by the expression of nestin and reside in specific regions of the brain, namely hippocampus, subventricular zone (SVZ), and olfactory bulb. For other brain structures, such as leptomeninges, which contribute to the correct cortex development and functions, there is no evidence so far that they may contain stem/precursor cells. In this work, we show for the first time that nestin-positive cells are present in rat leptomeninges during development up to adulthood. The newly identified nestin-positive cells can be extracted and expanded in vitro both as neurospheres, displaying high similarity with SVZ-derived neural stem cells, and as homogeneous cell population with stem cell features. In vitro expanded stem cell population can differentiate with high efficiency into excitable cells with neuronal phenotype and morphology. Once injected into adult brain, these cells survive and differentiate into neurons, thus showing that their neuronal differentiation potential is operational also in vivo. In conclusion, our data provide evidence that a specific population of immature cells endowed of neuronal differentiation potential is resident in the leptomeninges throughout the life. As leptomemniges cover the entire central nervous system, these findings could have relevant implications for studies on cortical development and for regenerative medicine applied to neurological disorders.
Id prodotto:
48840
Handle IRIS:
11562/327452
depositato il:
20 gennaio 2010
ultima modifica:
22 giugno 2018
Allegati:
1
Citazione bibliografica:
Bifari F.; Decimo I.; Chiamulera C.; Bersan E.; Malpeli G.; Johansson J.; Lisi V.; Bonetti B.; Fumagalli G.; Pizzolo G.; Krampera M., Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche «JOURNAL OF CELLULAR AND MOLECULAR MEDICINE» , vol. 13 , n. 9B2009pp. 3195-3208

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Titolo Dipartimento Responsabili
Utilizzo delle capacità rigenerative ed immunoregolatorie delle cellule staminali mesenchimali per il trattamento di patologie ossee, neurologiche e cardiologiche Dipartimento Diagnostica e Sanità Pubblica Guido Francesco Fumagalli
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