Pubblicazioni

Autori:

Conforti, Anita; Corsano, S.; Catalano, L.; Magro, Lara; Donati, M.; Leone, Roberto

Titolo:

Bisphosphonate-associated psychiatric adverse events: a signal from the Italian pharmacovigilance database

Anno:

2010

Tipologia prodotto:

Contributo in atti di convegno

Tipologia ANVUR:

Contributo in Atti di convegno

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Drug Safety

ISSN Rivista:

0114-5916

N° Volume:

33

Titolo del Convegno:

10th ISoP Annual Meeting

Luogo:

Accra, Ghana

Periodo:

3-6 November 2010

Editore:

ADIS

Casa editrice:

ADIS

Intervallo pagine:

940-941

Parole chiave:

Bisphosphonate; psychiatric adverse reactions; pharmacovigilance

Breve descrizione dei contenuti:

Background: Oral and intravenous bisphosphonates (alendronate, risedronate, pamidronate, ibandronate and zoledronate), used in oncology and for the treatment of osteoporosis, have been associated with different types of adverse reactions (ADRs) as oesophageal ulcer, influenza-like illness, hypocalcaemia, musculoskeletal pain, osteonecrosis of the jaw and ocular events. The frequency of these reactions is variable, in relation to the different single bisphosphonates, type of use, route of administration, dosage and duration of therapy. In literature no case of psychiatric disorders related to bisphosphonates is reported. The summary of product characteristics of pamidronate and zoledronate lists some psychiatric disorders as anxiety and sleep disturbances, all reported among uncommon events. No psychiatric adverse events are mentioned for the other bisphosphonates. Aim: To describe and discuss the spontaneous reports of psychiatric disorders associated to bisphosphonates in the Italian Pharmacovigilance Database. Methods: The database holds reports of suspected ADRs submitted since 1988. Within spontaneous reporting system in Italy the database is analysed twice in a year to filter out potential signals. Signal detection is done by qualitative case-by-case analysis and by using quantitative methodology like Proportional Reporting Ratio (PRR). Results: The database actually holds 110 497 reports, 90.1% of them coming from physicians, 4.9% from pharmacists, 1.4% from nurses and 0.3% from consumers. In 1260 reports a bisphosphonate is reported among the suspected drugs. Among these reports, 29 (2.3%) referred at least one psychiatric disorders. [...]

Id prodotto:

61370

Handle IRIS:

11562/360250

depositato il:

9 agosto 2011

ultima modifica:

3 novembre 2022

Citazione bibliografica:

Conforti, Anita; Corsano, S.; Catalano, L.; Magro, Lara; Donati, M.; Leone, Roberto, Bisphosphonate-associated psychiatric adverse events: a signal from the Italian pharmacovigilance database in «Drug Safety» vol. 33 ADIS , Atti di "10th ISoP Annual Meeting" , Accra, Ghana , 3-6 November 2010 , 2010 , pp. 940-941

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