Pubblicazioni

Autori:

Zanoni, A; Verlato, Giuseppe; Giacopuzzi, Simone; Weindelmayer, J; Casella, F; Pasini, Felice; Zhao, E; DE MANZONI, Giovanni

Titolo:

Neoadjuvant Concurrent Chemoradiotherapy for Locally Advanced Esophageal Cancer in a Single High-Volume Center.

Anno:

2013

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

ANNALS OF SURGICAL ONCOLOGY

ISSN Rivista:

1068-9265

N° Volume:

20

Numero o Fascicolo:

6

Intervallo pagine:

1993-1999

Parole chiave:

Esophageal Cancer; squamous cell carcinoma; adenocarcinoma; Neoadjuvant radiochemotherapy

Breve descrizione dei contenuti:

Background. Neoadjuvant chemoradiotherapy (CRT) is now considered the standard of care bymany centers in the treatment of both squamous cell carcinoma (SCC) and adenocarcinoma of the esophagus. This study evaluates the effectiveness of a neoadjuvant CRT protocol, as regards pathological complete response (pCR) rate and long-term survival.Methods. From 2003 to 2011, at Upper G.I. Surgery Division of Verona University, 155 consecutive patients with locally advanced esophageal cancers (90 SCC, 65 adenocarcinoma) were treated with a single protocol of neoadjuvant CRT (docetaxel, cisplatin, and 5-fluorouracil with 50.4 Gy of concurrent radiotherapy). Response to CRT was evaluated through percentage of pathological complete response (pCR or ypT0N0), overall (OS) and disease-related survival (DRS), and pattern of relapse.Results. One hundred thirty-one patients (84.5 %) underwent surgery. Radical resection (R0) was achieved in 123 patients (79.3 %), and pCR in 65 (41.9 %). Postoperative mortality was 0.7 % (one case). Five-year OS and DRS were respectively 43 and 49 % in the entire cohort, 52 and 59 % in R0 cases, and 72 and 81 % in pCR cases. Survival did not significantly differ between SCC and adenocarcinoma, except for pCR cases. Forty-nine patients suffered from relapse, which was mainly systemic in adenocarcinoma. Only three out of 26 pCR patients with previous adenocarcinoma developed relapse, always systemic.Conclusions. This study suggests that patients treated with the present protocol achieve good survival and high pCR rate. Further research is necessary to evaluate whether surgery on demand is feasible in selected patients, such as pCR patients with adenocarcinoma.

Id prodotto:

81323

Handle IRIS:

11562/495153

depositato il:

15 maggio 2014

ultima modifica:

6 giugno 2023

Citazione bibliografica:

Zanoni, A; Verlato, Giuseppe; Giacopuzzi, Simone; Weindelmayer, J; Casella, F; Pasini, Felice; Zhao, E; DE MANZONI, Giovanni, Neoadjuvant Concurrent Chemoradiotherapy for Locally Advanced Esophageal Cancer in a Single High-Volume Center. «ANNALS OF SURGICAL ONCOLOGY» , vol. 20 , n. 6 , 2013 , pp. 1993-1999

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