Pubblicazioni

Autori:

Berton, Valeria; Decimo, Ilaria; Bifari, Francesco; Krampera, Mauro; Fumagalli, Guido Francesco

Titolo:

In vitro characterization of the differentiation of meningeal stem/precursor cells into the oligodendrocyte lineage

Anno:

2012

Tipologia prodotto:

Abstract in Atti di convegno

Tipologia ANVUR:

Abstract in Atti di convegno

Lingua:

Inglese

Formato:

Elettronico

Titolo del Convegno:

Summer School: Neural Stem Cells in Development and Disease

Luogo:

Levico Terme

Periodo:

4-8/09/2012

Intervallo pagine:

6-6

Parole chiave:

neural stem cells, oligodendrocyte differentiation

Breve descrizione dei contenuti:

In most diseases of the spinal cord, demyelination plays an important role in the generation and progression of the neurodegenerative lesion. Despite the fact that the spinal cord shows potential for regeneration of Schwann cells, this is limited and apparently insufficient for repair. Attempts to establish regenerative approaches by neural stem cell transplantation have been so far limited by lack of knowledge of the function of resident SCs and of adequate sources of cells. We have recently described that Leptomeninges of the spinal cord are a niche for neural stem cells (Decimo et al, 2011). These Leptomeningeal Stem Cells (LeSCs) are endowed with self-renewal properties and can differentiate into neurons and oligodendrocytes when stimulated with the appropriate factors. Considering that remyelinization may be a realistic and efficient goal for transplantation-based regenerative therapies of the spinal cord, we decided to define conditions for efficient and high-yield generation of precursor and differentiated cells of the oligodendrocyte lineage. In conclusion, we have established an efficient and reproducible method to generate large numbers of cells of oligodendrocyte-lineage at different and controlled levels of differentiation. Testing of remyelinization efficiency by different sets of cells will be performed in vitro and by transplantation experiments in vivo using animal models of traumatic lesion of the spinal cord and of multiple sclerosis.

Id prodotto:

76089

Handle IRIS:

11562/499549

depositato il:

4 febbraio 2013

ultima modifica:

14 novembre 2022

Citazione bibliografica:

Berton, Valeria; Decimo, Ilaria; Bifari, Francesco; Krampera, Mauro; Fumagalli, Guido Francesco, In vitro characterization of the differentiation of meningeal stem/precursor cells into the oligodendrocyte lineage  in Summer School: Neural Stem Cells in Development and Disease Abstracts CD , Atti di "Summer School: Neural Stem Cells in Development and Disease" , Levico Terme , 4-8/09/2012 , 2012 , pp. 6-6

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