Pubblicazioni

Migration of meningeal cells in response to contusive spinal cord injury  (2012)

Autori:
BERTON VALERIA; BIFARI FRANCESCO; RODRIGUEZ FRANCISCO JAVIER; KRAMPERA MAURO; FUMAGALLI GUIDO; DECIMO ILARIA
Titolo:
Migration of meningeal cells in response to contusive spinal cord injury
Anno:
2012
Tipologia prodotto:
Abstract in Atti di convegno
Tipologia ANVUR:
Abstract in Atti di convegno
Nazioni degli autori:
SPAGNA; ITALIA
Lingua:
Inglese
Formato:
A Stampa
Titolo del Convegno:
The Show of regeneration - Easy to see hard to foresee
Luogo:
Berlin
Periodo:
4-7/12/2012
Intervallo pagine:
40-40
Parole chiave:
NEURAL STEM CELLS, SPINAL CORD INJURY, MIGRATION
Breve descrizione dei contenuti:
Recently, we have characterized adult brain and spinal cord meninges and demonstrated that meninges contain nestin-positive cells, endowed with self-renewal and proliferative properties, and neural precursor doublecortin (DCX)-positive cells (Bifari et la 2009, Decimo et al 2011). Cells extracted from meninges can be expanded as neurospheres and induced to specifically differentiate in vitro into either functional neurons or mature oligodendrocytes. Strikingly, following contusive spinal cord injury (SCI), meningeal stem/precursor cells proliferate and increase in number, suggesting that they are activated by injury. In this study we ask whether activated menigneal stem/precursor cells migrate from meninges to parenchyma upon injury-induced activation. In order to trace the meningeal stem/precursor cells we transduced meningeal cells in vivo with a lentiviral GFP vector.We found that meningeal stem/precursor cells migrate to the lesion site, express neuronal markers and persist in this region until 1 month post injury. This results suggest that meningeal stem/precursor cells may have a role in the parenchymal regenerative potential following SCI.
Id prodotto:
76088
Handle IRIS:
11562/500363
depositato il:
18 novembre 2015
ultima modifica:
2 novembre 2016
Citazione bibliografica:
BERTON VALERIA; BIFARI FRANCESCO; RODRIGUEZ FRANCISCO JAVIER; KRAMPERA MAURO; FUMAGALLI GUIDO; DECIMO ILARIA, Migration of meningeal cells in response to contusive spinal cord injury  in The Show of regeneration - Easy to see hard to foresee Abstracts BookAtti di "The Show of regeneration - Easy to see hard to foresee" , Berlin , 4-7/12/2012 , 2012pp. 40-40

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

Progetti Collegati
Titolo Dipartimento Responsabili
Adult spinal cord meninges: a new source of neural stem cell for regenerative medicine Dipartimento Diagnostica e Sanità Pubblica Guido Francesco Fumagalli
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