Pubblicazioni

Autori:

Vinante, Fabrizio; Tomei, Paola; Zaza, Gianluigi; Zamo', Alberto; Lupo, Antonio

Titolo:

Hairy cell leukemia in kidney transplantation: lesson from a rare disorder.

Anno:

2013

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

EXPERIMENTAL HEMATOLOGY & ONCOLOGY

ISSN Rivista:

2162-3619

N° Volume:

2

Numero o Fascicolo:

22

Intervallo pagine:

1-5

Parole chiave:

Hairy cell leukemia; Kidney transplantation; Calcineurin inhibitors

Breve descrizione dei contenuti:

We report here on the diagnosis and successful treatment of a case of hairy cell leukemia (HCL) that arose 15 years after kidney transplantation in a 51-year-old patient. As soon as the diagnosis was made, HCL was treated with 2-CDA, obtaining complete hematological remission. Immunosuppression with the calcineurin inhibitor cyclosporin was maintained, and the graft was preserved. In kidney transplant recipients supported with immunosuppressive drugs, post-transplant lymphoproliferative diseases (PTLDs) are frequent and typically related to immunosuppression via a loss of control of infectious/EBV-related proliferative stimuli. To date, HCL has not been considered among PTLDs. Recently, however, the oncogenic mutation V600E of the BRAF protein kinase has been found to be a hallmark of HCL, and calcineurin inhibitors have been shown to interfere with signaling downstream of V600E BRAF early on by counteracting senescence-associated mechanisms that protect against the oncogenic potential of the mutated kinase. Such a biochemical link between the oncogene-dependent signaling and calcineurin inhibitor activities suggests that HCL in transplanted patients might be a peculiar type of PTLD based on the presence of a specific mutation. This mechanism might also be involved in other neoplasias bearing the same or similar mutations, such as melanoma and non-melanoma skin cancer.

Pagina Web:

http://ehoonline.biomedcentral.com/articles/10.1186/2162-3619-2-22

Id prodotto:

77834

Handle IRIS:

11562/613751

depositato il:

25 settembre 2013

ultima modifica:

14 novembre 2022

Citazione bibliografica:

Vinante, Fabrizio; Tomei, Paola; Zaza, Gianluigi; Zamo', Alberto; Lupo, Antonio, Hairy cell leukemia in kidney transplantation: lesson from a rare disorder. «EXPERIMENTAL HEMATOLOGY & ONCOLOGY» , vol. 2 , n. 22 , 2013 , pp. 1-5

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