Pubblicazioni

Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues.  (2013)

Autori:
Di Trapani, Mariano; Bassi, Giulio; Ricciardi, Mario; Fontana, Emanuela; Bifari, Francesco; Pacelli, Luciano; Giacomello, Luca; Pozzobon, M; Féron, F; De Coppi, P; Anversa, P; Fumagalli, Guido Francesco; Decimo, Ilaria; Menard, C; Tarte, K; Krampera, Mauro
Titolo:
Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues.
Anno:
2013
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
A Stampa
Referee:
Nome rivista:
STEM CELLS AND DEVELOPMENT
ISSN Rivista:
1547-3287
N° Volume:
22
Numero o Fascicolo:
22
Intervallo pagine:
2990-3002
Parole chiave:
adult stem cells
Breve descrizione dei contenuti:
Allogeneic stem cell-based therapy is a promising tool for the treatment of a range of human degenerative and inflammatory diseases. Many reports highlighted the immune modulatory properties of some stem cell (SC) types, such as mesenchymal stromal cells (MSCs), but a comparative study with SCs of different origin, to assess whether immune regulation is a general SC property, is still lacking. To this aim, we applied highly standardized methods employed for MSC characterization to compare the immunological properties of bone marrow-MSCs, olfactory ecto-mesenchymal stem cells, leptomeningeal stem cells, and three different c-Kit-positive SC types, i.e. amniotic fluid SCs, cardiac SCs, and lung SCs. We found that all the analyzed human SCs share a common pattern of immunological features, in terms of expression of activation markers ICAM-1, VCAM-1, HLA-ABC and HLA-DR, modulatory activity towards purified T, B and NK cells, lower immunogenicity of inflammatory-primed SCs as compared to resting SCs, and IDO-activation as molecular inhibitory pathways, with some SC type-related peculiarities. Moreover, the SC types analyzed exert an anti-apoptotic effect towards not-activated immune effector cells. In addition, we found that the inhibitory behavior is not a constitutive property of SCs, but is acquired as a consequence of immune effector cell activation, as previously described for MSCs. Thus, immune regulation is a general property of stem cells and the characterization of this phenomenon may be useful for a proper therapeutic use of SCs.
Id prodotto:
77747
Handle IRIS:
11562/614953
depositato il:
16 settembre 2013
ultima modifica:
28 ottobre 2020
Citazione bibliografica:
Di Trapani, Mariano; Bassi, Giulio; Ricciardi, Mario; Fontana, Emanuela; Bifari, Francesco; Pacelli, Luciano; Giacomello, Luca; Pozzobon, M; Féron, F; De Coppi, P; Anversa, P; Fumagalli, Guido Francesco; Decimo, Ilaria; Menard, C; Tarte, K; Krampera, Mauro, Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues. «STEM CELLS AND DEVELOPMENT» , vol. 22 , n. 222013pp. 2990-3002

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

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