- Autori:
-
Di Trapani, Mariano; Bassi, Giulio; Ricciardi, Mario; Fontana, Emanuela; Bifari, Francesco; Pacelli, Luciano; Giacomello, Luca; Pozzobon, M; Féron, F; De Coppi, P; Anversa, P; Fumagalli, Guido Francesco; Decimo, Ilaria; Menard, C; Tarte, K; Krampera, Mauro
- Titolo:
-
Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues.
- Anno:
-
2013
- Tipologia prodotto:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Lingua:
-
Inglese
- Formato:
-
A Stampa
- Referee:
-
Sì
- Nome rivista:
- STEM CELLS AND DEVELOPMENT
- ISSN Rivista:
- 1547-3287
- N° Volume:
-
22
- Numero o Fascicolo:
-
22
- Intervallo pagine:
-
2990-3002
- Parole chiave:
-
adult stem cells
- Breve descrizione dei contenuti:
- Allogeneic stem cell-based therapy is a promising tool for the treatment of a range of human degenerative and inflammatory diseases. Many reports highlighted the immune modulatory properties of some stem cell (SC) types, such as mesenchymal stromal cells (MSCs), but a comparative study with SCs of different origin, to assess whether immune regulation is a general SC property, is still lacking. To this aim, we applied highly standardized methods employed for MSC characterization to compare the immunological properties of bone marrow-MSCs, olfactory ecto-mesenchymal stem cells, leptomeningeal stem cells, and three different c-Kit-positive SC types, i.e. amniotic fluid SCs, cardiac SCs, and lung SCs. We found that all the analyzed human SCs share a common pattern of immunological features, in terms of expression of activation markers ICAM-1, VCAM-1, HLA-ABC and HLA-DR, modulatory activity towards purified T, B and NK cells, lower immunogenicity of inflammatory-primed SCs as compared to resting SCs, and IDO-activation as molecular inhibitory pathways, with some SC type-related peculiarities. Moreover, the SC types analyzed exert an anti-apoptotic effect towards not-activated immune effector cells. In addition, we found that the inhibitory behavior is not a constitutive property of SCs, but is acquired as a consequence of immune effector cell activation, as previously described for MSCs. Thus, immune regulation is a general property of stem cells and the characterization of this phenomenon may be useful for a proper therapeutic use of SCs.
- Id prodotto:
-
77747
- Handle IRIS:
-
11562/614953
- depositato il:
-
16 settembre 2013
- ultima modifica:
-
15 novembre 2022
- Citazione bibliografica:
-
Di Trapani, Mariano; Bassi, Giulio; Ricciardi, Mario; Fontana, Emanuela; Bifari, Francesco; Pacelli, Luciano; Giacomello, Luca; Pozzobon, M; Féron, F; De Coppi, P; Anversa, P; Fumagalli, Guido Francesco; Decimo, Ilaria; Menard, C; Tarte, K; Krampera, Mauro,
Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues.
«STEM CELLS AND DEVELOPMENT»
, vol.
22
, n.
22
,
2013
,
pp. 2990-3002
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