PURPOSE:
The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens.
METHODS:
VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters.
RESULTS:
In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis.
CONCLUSIONS:
Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk.
Note:
pii: S0748-7983(14)00395-3
Id prodotto:
81093
Handle IRIS:
11562/718965
depositato il:
26 settembre 2014
ultima modifica:
11 novembre 2022
Citazione bibliografica:
Lastraioli, E; Boni, L; Romoli, Mr; Crescioli, S; Taddei, A; Beghelli, Stefania; Tomezzoli, Anna; Vindigni, C; Saragoni, L; Messerini, L; Bernini, M; Bencini, L; Giommoni, E; Freschi, G; Di Costanzo, F; Scarpa, Aldo; Morgagni, P; Farsi, M; Roviello, F; DE MANZONI, Giovanni; Bechi, P; Arcangeli, A; Gruppo Italiano di Ricerca Cancro, Gastrico,
VEGF-A clinical significance in gastric cancers: Immunohistochemical analysis of a wide Italian cohort«European Journal of Surgical Oncology»
, vol. 40
, n. 10
, 2014
, pp. 1291-1298