Pubblicazioni

Autori:

Pedica, Federica; Ruzzenente, Andrea; Bagante, Fabio; Capelli, Paola; Cataldo, Ivana; Pedron, Serena; Iacono, Calogero; Chilosi, Marco; Scarpa, Aldo; Brunelli, Matteo; Tomezzoli, Anna; Martignoni, Guido; Guglielmi, Alfredo

Titolo:

A re-emerging marker for prognosis in hepatocellular carcinoma: the add-value of fishing c-myc gene for early relapse.

Anno:

2013

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

PLoS ONE

ISSN Rivista:

1932-6203

N° Volume:

8

Intervallo pagine:

e68203-e68214

Parole chiave:

Aged, Carcinoma; Hepatocellular; diagnosis/genetics/mortality/pathology, Early Detection of Cancer; methods, Female, Genes; myc; physiology, Humans, In Situ Hybridization; Fluorescence, Liver Neoplasms; diagnosis/genetics/mortality/pathology, Male, Middle Aged, Neoplasm Recurrence; Local; diagnosis/genetics, Predictive Value of Tests, Prognosis, Recurrence, Tumor Markers; Biological; analysis/physiology

Breve descrizione dei contenuti:

Hepatocellular carcinoma is one leading cause of cancer-related death and surgical resection is still one of the major curative therapies. Recently, there has been a major effort to find mechanisms involved in carcinogenesis and early relapse. c-myc gene abnormality is found in hepatocarcinogenesis. Our aim was to analyze the role of c-myc as prognostic factor in terms of overall survival and disease-free survival and to investigate if c-myc may be an important target for therapy. We studied sixty-five hepatocellular carcinomas submitted to surgical resection with curative intent. Size, macro-microvascular invasion, necrosis, number of nodules, grading and serum alfa-fetoprotein level were registered for all cases. We evaluated the c-myc aberrations by using break-apart FISH probes. Probes specific for the centromeric part of chromosome 8 and for the locus specific c-myc gene (8q24) were used to assess disomy, gains of chromosomes (polysomy due to polyploidy) and amplification. c-myc gene amplification was scored as 8q24/CEP8 > 2. Statistical analysis for disease-free survival and overall survival were performed. At molecular level, c-myc was amplified in 19\% of hepatocellular carcinoma, whereas showed gains in 55\% and set wild in 26\% of cases. The 1- and 3-year disease-free survival and overall survival for disomic, polysomic and amplified groups were significantly different (p=0.020 and p=.018 respectively). Multivariate analysis verified that the AFP and c-myc status (amplified vs. not amplified) were significant prognostic factors for overall patients survival. c-myc gene amplification is significantly correlated with disease-free survival and overall survival in patients with hepatocellular carcinoma after surgical resection and this model identifies patients with risk of early relapse (≤12 months). We suggest that c-myc assessment may be introduced in the clinical practice for improving prognostication (high and low risk of relapse) routinely and may have be proposed as biomarker of efficacy to anti-c-myc targeted drugs in clinical trials.

Pagina Web:

http://dx.doi.org/10.1371/journal.pone.0068203

Id prodotto:

82388

Handle IRIS:

11562/761763

depositato il:

7 agosto 2014

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Pedica, Federica; Ruzzenente, Andrea; Bagante, Fabio; Capelli, Paola; Cataldo, Ivana; Pedron, Serena; Iacono, Calogero; Chilosi, Marco; Scarpa, Aldo; Brunelli, Matteo; Tomezzoli, Anna; Martignoni, Guido; Guglielmi, Alfredo, A re-emerging marker for prognosis in hepatocellular carcinoma: the add-value of fishing c-myc gene for early relapse. «PLoS ONE» , vol. 8 , 2013 , pp. e68203-e68214

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