Pubblicazioni

Autori:

Cingarlini, Sara; Ortolani, Silvia; Salgarello, Matteo; Butturini, Giovanni; Malpaga, Anna; Malfatti, Veronica; D'Onofrio, Mirko; Davi', Maria Vittoria; Vallerio, Paola; Ruzzenente, Andrea; Capelli, Paola; Citton, Elia; Grego, Elisabetta; Trentin, Chiara; DE ROBERTIS LOMBARDI, Riccardo; Scarpa, Aldo; Bassi, Claudio; Tortora, Giampaolo

Titolo:

Role of Combined Ga-68-DOTATOC and F-18-FDG Positron Emission Tomography/Computed Tomography in the Diagnostic Workup of Pancreas Neuroendocrine Tumors Implications for Managing Surgical Decisions

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

Sì

Nome rivista:

Pancreas

ISSN Rivista:

0885-3177

N° Volume:

46

Numero o Fascicolo:

1

Intervallo pagine:

42-47

Parole chiave:

pancreas neuroendocrine tumors (PanNETs), Ga-DOTATOC (Ga) positron emission tomography (PET)/computed tomography (CT)

Breve descrizione dei contenuti:

Objectives: Ga-68-DOTATOC (Ga) positron emission tomography (PET)/computed tomography (CT) is recommended in the workup of pancreas neuroendocrine tumors (PanNETs); evidence suggests that F-18-FDG (F) PET/CT can also provide prognostic information. Aims of this study were to assess the role of combined Ga-and F-PET/CT in the evaluation of grade (G) 1-2 PanNETs and to test the correlation between F-PET/CT positivity and tumor grade.Methods: Preoperative Ga-and F-PET/CT of 35 patients with surgically resected G1-2 PanNETs were evaluated. For grading, the 2010 World Health Organization Classification was used; an ancillary analysis with Ki67 cutoffs at 5% to 20% was conducted. Correlation between F-PET/ CT positivity (SUVmax > 3.5) and grade was assessed.Results: Of 35 PanNETs, 28.6% and 71.4% were G1 and G2 as per World Health Organization. Ga-PET/CT showed high sensitivity (94.3%) in detecting G1-2 PanNETs. F-PET/CT was positive in 20% and 76% G1 and G2 tumors (P = 0.002). F-PET/CT identified G2 PanNETs with high positive predictive value (PPV, 90.5%). F-PET/CT correlated with tumor grade also in the ancillary analysis (P = 0.009).Conclusions: The high sensitivity of Ga-PET/CT in NET detection is known. The high PPV of F-PET/CT in the identification of G2 forms suggests its potential role in PanNETs prognostication and risk stratification.

Id prodotto:

95066

Handle IRIS:

11562/955133

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Cingarlini, Sara; Ortolani, Silvia; Salgarello, Matteo; Butturini, Giovanni; Malpaga, Anna; Malfatti, Veronica; D'Onofrio, Mirko; Davi', Maria Vittoria; Vallerio, Paola; Ruzzenente, Andrea; Capelli, Paola; Citton, Elia; Grego, Elisabetta; Trentin, Chiara; DE ROBERTIS LOMBARDI, Riccardo; Scarpa, Aldo; Bassi, Claudio; Tortora, Giampaolo, Role of Combined Ga-68-DOTATOC and F-18-FDG Positron Emission Tomography/Computed Tomography in the Diagnostic Workup of Pancreas Neuroendocrine Tumors Implications for Managing Surgical Decisions «Pancreas» , vol. 46 , n. 1 , 2017 , pp. 42-47

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