Pubblicazioni

Autori:

Mastracci, L; Piol, N; Molinaro, L; Pitto, F; Tinelli, C; De Silvestri, A; Fiocca, R; Grillo, F; ABRAM Study Group collaborators: Alò, P; Al Omoush, Tm; Asioli, S; Buffelli, F; Conforti, F; Cornaggia, M; Cossu, S; D'Armiento, Fp; De Marco, L; Fiocca, R; Foscolo, Am; Fraternali Orcioni, G; Ingravallo, G; Locatelli, F; Luinetti, O; Marchio, C; Montinari, E; Melchiorri, L; Messerini, L; Migliora, P; Pizzi, M; Rugge, M; Saragoni, L; Tamponi, E; Tomezzoli, Anna; Trisolini, Mp; Trombatore, M; Vanoli, A; Vellone, Vg; Villanacci, V.

Titolo:

Interobserver reproducibility in pathologist interpretation of columnar-lined esophagus

Anno:

2016

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

VIRCHOWS ARCHIV

ISSN Rivista:

0945-6317

N° Volume:

468

Numero o Fascicolo:

2

Editore:

Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229

Intervallo pagine:

159-167

Parole chiave:

Barrett’s esophagus; Columnar-lined esophagus; Histological diagnosis; Interobserver variation; Adult; Aged; Barrett Esophagus; Biopsy; Epithelium; Esophageal Neoplasms; Esophagus; Humans; Metaplasia; Middle Aged; Reproducibility of Results

Breve descrizione dei contenuti:

Confirmation of endoscopically suspected esophageal metaplasia (ESEM) requires histology, but confusion in the histological definition of columnar-lined esophagus (CLE) is a longstanding problem. The aim of this study is to evaluate interpathologist variability in the interpretation of CLE. Thirty pathologists were invited to review three ten-case sets of CLE biopsies. In the first set, the cases were provided with descriptive endoscopy only; in the second and the third sets, ESEM extent using Prague criteria was provided. Moreover, participants were required to refer to a diagnostic chart for evaluation of the third set. Agreement was statistically assessed using Randolph's free-marginal multirater kappa. While substantial agreement in recognizing columnar epithelium (K = 0.76) was recorded, the overall concordance in clinico-pathological diagnosis was low (K = 0.38). The overall concordance rate improved from the first (K = 0.27) to the second (K = 0.40) and third step (K = 0.46). Agreement was substantial when diagnosing Barrett's esophagus (BE) with intestinal metaplasia or inlet patch (K = 0.65 and K = 0.89), respectively, in the third step, while major problems in interpretation of CLE were observed when only cardia/cardia-oxyntic atrophic-type epithelium was present (K = 0.05-0.29). In conclusion, precise endoscopic description and the use of a diagnostic chart increased consistency in CLE interpretation of esophageal biopsies. Agreement was substantial for some diagnostic categories (BE with intestinal metaplasia and inlet patch) with a well-defined clinical profile. Interpretation of cases with cardia/cardia-oxyntic atrophic-type epithelium, with or without ESEM, was least consistent, which reflects lack of clarity of definition and results in variable management of this entity.

Id prodotto:

98762

Handle IRIS:

11562/967961

ultima modifica:

30 novembre 2022

Citazione bibliografica:

Mastracci, L; Piol, N; Molinaro, L; Pitto, F; Tinelli, C; De Silvestri, A; Fiocca, R; Grillo, F; ABRAM Study Group collaborators: Alò, P; Al Omoush, Tm; Asioli, S; Buffelli, F; Conforti, F; Cornaggia, M; Cossu, S; D'Armiento, Fp; De Marco, L; Fiocca, R; Foscolo, Am; Fraternali Orcioni, G; Ingravallo, G; Locatelli, F; Luinetti, O; Marchio, C; Montinari, E; Melchiorri, L; Messerini, L; Migliora, P; Pizzi, M; Rugge, M; Saragoni, L; Tamponi, E; Tomezzoli, Anna; Trisolini, Mp; Trombatore, M; Vanoli, A; Vellone, Vg; Villanacci, V., Interobserver reproducibility in pathologist interpretation of columnar-lined esophagus «VIRCHOWS ARCHIV» , vol. 468 , n. 2 , 2016 , pp. 159-167

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo