Pubblicazioni

Autori:

Andersen, Zorana J; Stafoggia, Massimo; Weinmayr, Gudrun; Pedersen, Marie; Galassi, Claudia; Jørgensen, Jeanette T; Oudin, Anna; Forsberg, Bertil; Olsson, David; Oftedal, Bente; Marit Aasvang, Gunn; Aamodt, Geir; Pyko, Andrei; Pershagen, Göran; Korek, Michal; De Faire, Ulf; Pedersen, Nancy L; Östenson, Claes göran; Fratiglioni, Laura; Eriksen, Kirsten T; Tjønneland, Anne; Peeters, Petra H; Bueno de mesquita, Bas; Plusquin, Michelle; Key, Timothy J; Jaensch, Andrea; Nagel, Gabriele; Lang, Alois; Wang, Meng; Tsai, Ming yi; Fournier, Agnes; Boutron ruault, Marie christine; Baglietto, Laura; Grioni, Sara; Marcon, Alessandro; Krogh, Vittorio; Ricceri, Fulvio; Sacerdote, Carlotta; Migliore, Enrica; Tamayo uria, Ibon; Amiano, Pilar; Dorronsoro, Miren; Vermeulen, Roel; Sokhi, Ranjeet; Keuken, Menno; De Hoogh, Kees; Beelen, Rob; Vineis, Paolo; Cesaroni, Giulia; Brunekreef, Bert; Hoek, Gerard; Raaschou nielsen, Ole

Titolo:

Long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in 15 European cohorts within the ESCAPE project

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

Sì

Nome rivista:

ENVIRONMENTAL HEALTH PERSPECTIVES

ISSN Rivista:

1552-9924

N° Volume:

125

Numero o Fascicolo:

10

Intervallo pagine:

N/A-N/A

Parole chiave:

air pollution; cancer; breast; epidemiology; ESCAPE; women; Europe; Particulate matter; PM10; PM2.5; Nitrogen dioxides; NO2

Breve descrizione dei contenuti:

BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women. METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts - Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2.5μm, ≤10μm, and 2.5-10μm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses. RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m3}, PM10 [1.07 (95% CI: 0.89, 1.30) per 10 μg/m3], PMcoarse [1.20 (95% CI: 0.96, 1.49 per 5 μg/m3], and NO2 [1.02 (95% CI: 0.98, 1.07 per 10 μg/m3], and a statistically significant association with NOx [1.04 (95% CI: 1.00, 1.08) per 20 μg/m3, p=0.04]. CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women.

Note:

L’articolo deriva dalla collaborazione internazionale ESCAPE - European Study of Cohorts for Air Pollution Effects, un progetto coordinato dal Prof. Bert Brunekreef, Università di Utrecht (NL). Lo studio è stato finanziato dall’Unione Europea mediante bando competitivo con revisione tra pari (7th Framework Programme Theme, ENV.2007.1.2.2.2). Il metodo di exposure assessment sviluppato in ESCAPE prevedeva il monitoraggio standardizzato e coordinato di ossidi di azoto, particolato sottile e suoi componenti in numerose città europee, seguito dall’assegnazione di stime di esposizione (ottenute mediante modelli Land Use Regression) agli indirizzi di residenza dei partecipanti.

Pagina Web:

https://doi.org/10.1289/EHP1742
https://ehp.niehs.nih.gov/doi/10.1289/EHP1742

Id prodotto:

99042

Handle IRIS:

11562/969108

ultima modifica:

23 febbraio 2023

Citazione bibliografica:

Andersen, Zorana J; Stafoggia, Massimo; Weinmayr, Gudrun; Pedersen, Marie; Galassi, Claudia; Jørgensen, Jeanette T; Oudin, Anna; Forsberg, Bertil; Olsson, David; Oftedal, Bente; Marit Aasvang, Gunn; Aamodt, Geir; Pyko, Andrei; Pershagen, Göran; Korek, Michal; De Faire, Ulf; Pedersen, Nancy L; Östenson, Claes göran; Fratiglioni, Laura; Eriksen, Kirsten T; Tjønneland, Anne; Peeters, Petra H; Bueno de mesquita, Bas; Plusquin, Michelle; Key, Timothy J; Jaensch, Andrea; Nagel, Gabriele; Lang, Alois; Wang, Meng; Tsai, Ming yi; Fournier, Agnes; Boutron ruault, Marie christine; Baglietto, Laura; Grioni, Sara; Marcon, Alessandro; Krogh, Vittorio; Ricceri, Fulvio; Sacerdote, Carlotta; Migliore, Enrica; Tamayo uria, Ibon; Amiano, Pilar; Dorronsoro, Miren; Vermeulen, Roel; Sokhi, Ranjeet; Keuken, Menno; De Hoogh, Kees; Beelen, Rob; Vineis, Paolo; Cesaroni, Giulia; Brunekreef, Bert; Hoek, Gerard; Raaschou nielsen, Ole, Long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in 15 European cohorts within the ESCAPE project «ENVIRONMENTAL HEALTH PERSPECTIVES» , vol. 125 , n. 10 , 2017 , pp. N/A-N/A

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