Pubblicazioni

Autori:

Ferrarini, Isacco; Rigo, Antonella; Zamò, Alberto; Vinante, Fabrizio

Titolo:

Classical Hodgkin lymphoma cells may promote an IL-17-enriched microenvironment

Anno:

2019

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Leukemia and Lymphoma

ISSN Rivista:

1042-8194

Intervallo pagine:

1-11

Parole chiave:

CD30; Interleukin 17; T helper lymphocytes; classical Hodgkin lymphoma; microenvironment

Breve descrizione dei contenuti:

In classical Hodgkin lymphoma (cHL), the significance of the interplay between Hodgkin and Reed-Sternberg cells (HRS) and reactive T cells remains poorly defined. By immunohistochemistry on bioptic cHL specimens, we found that HRS and surrounding T lymphocytes stained positive for IL-17 in 40% of cases. IL-17 was detectable in a similar proportion of patients' sera and correlated with disease burden. Supernatants of KM-H2 and HDLM-2 cHL cell lines guided preferential chemotaxis of CCR6(+) T lymphocytes. Coculture of cHL cell lines with PBMC promoted the enrichment of Th17 lymphocytes and Foxp3(+)/IL-17(+) cells, whereas T regulatory cells slightly decreased. Soluble CD30 downmodulated membrane CD30 expression on T cells and contributed to their polarization shift by stimulating IL-17 production and reducing IFN-gamma synthesis. Thus, HRS and a number of reactive CD4(+) T cells, attracted by tumor-secreted chemokines, produce an IL-17 tumor-shaped inflammatory milieu in a cHL subset.

Id prodotto:

109975

Handle IRIS:

11562/999250

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Ferrarini, Isacco; Rigo, Antonella; Zamò, Alberto; Vinante, Fabrizio, Classical Hodgkin lymphoma cells may promote an IL-17-enriched microenvironment «Leukemia and Lymphoma» , 2019 , pp. 1-11

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo