The research group study application of the interphase cytogenetic FISH analysis on formalin-fixed and paraffin embedded tissue for diagnostics, prognostication and predictiveness to targeted therapies in carcinoma primary arising from the urogenital tract (i.e. renal cell carcinoma), in breast carcinoma (Her-2 locus gene) and ALK/ROS-1 riarrangements in lung carcinoma; moreover application of FISH technique for 1p/19q abnormalities in tumours from the central nervous system is constantly performed. Prof. Guido Martignoni and Dr. Anna Caliò partecipate in the research group from more than a decade. The group published more than 100 manuscripts by using FISH analysis as primary mehtod of cancer discovery.