Publications

Authors:

Accordini, Simone; Calciano, Lucia; Marcon, Alessandro; Pesce, Giancarlo; M Antó, Josep; B Beckmeyer-Borowko, Anna; Carsin, Anne-Elie; Corsico, Angelo Guido; Imboden, Medea; Janson, Christer; Keidel, Dirk; Locatelli, Francesca; Svanes, Cecilie; GJ Burney, Peter; Jarvis, Deborah; M Probst-Hensch, Nicole; Minelli, Cosetta

Title:

Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

SCIENTIFIC REPORTS

ISSN of journal:

2045-2322

N° Volume:

10

Number or Folder:

1

Page numbers:

1-9

Keyword:

Ageing Lungs in European Cohorts (ALEC) Study, airflow obstruction, cohort study, European Community Respiratory Health Survey (ECRHS), incidence, Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), tobacco smoking, trend

Short description of contents:

Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this information to estimate the incidence of post-bronchodilator AO (AOpost-BD), which is the primary characteristic of COPD. AO incidence was 4.4 (95%CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males; 12, females), AO incidence significantly increased with ageing in men only [incidence rate ratio (IRR), 1-year increase: 1.05 (1.03-1.07)]. A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increase: 1.03 (1.02-1.04)] and females [1.03 (1.02-1.05)]. The positive predictive value of AO for AOpost-BD was 59.1% (52.0-66.2%) in men and 42.6% (35.1-50.1%) in women. AOpost-BD incidence was 2.6 (1.7-3.4) male and 1.6 (1.0-2.2) female cases/1,000/year. AO incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers was strongly related to cumulative tobacco exposure. AOpost-BD incidence is expected to be half of AO incidence.

Web page:

https://rdcu.be/b2cY2

Product ID:

113083

Handle IRIS:

11562/1012426

Last Modified:

November 25, 2022

Bibliographic citation:

Accordini, Simone; Calciano, Lucia; Marcon, Alessandro; Pesce, Giancarlo; M Antó, Josep; B Beckmeyer-Borowko, Anna; Carsin, Anne-Elie; Corsico, Angelo Guido; Imboden, Medea; Janson, Christer; Keidel, Dirk; Locatelli, Francesca; Svanes, Cecilie; GJ Burney, Peter; Jarvis, Deborah; M Probst-Hensch, Nicole; Minelli, Cosetta, Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study «SCIENTIFIC REPORTS» , vol. 10 , n. 1 , 2020 , pp. 1-9

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo