Publications

Authors:

Politi, Leonardo; Monasta, Lorenzo; Rigressi, Maria Novella; Princivalle, Andrea; Gonfiotti, Alessandro; Camiciottoli, Gianna; Perbellini, Luigi

Title:

Discriminant Profiles of Volatile Compounds in the Alveolar Air of Patients with Squamous Cell Lung Cancer, Lung Adenocarcinoma or Colon Cancer

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

MOLECULES

ISSN of journal:

1420-3049

N° Volume:

26

Number or Folder:

3

Page numbers:

1-22

Keyword:

alveolar air; colon cancer; ion-molecule reaction mass spectrometry (IMR-MS); lung adenocarcinoma; squamous cell lung cancer; volatile compounds

Short description of contents:

The objective of the present work was to analyze volatile compounds in alveolar air in patients with squamous cell lung cancer, lung adenocarcinoma or colon cancer, to prepare algorithms able to discriminate such specific pathological conditions. The concentration of 95 volatile com-pounds was measured in the alveolar air of 45 control subjects, 36 patients with lung adenocarci-noma, 25 patients with squamous cell lung cancer and 52 patients with colon cancer. Volatile compounds were measured with ion molecule reaction mass spectrometry (IMR-MS). An iterat-ed least absolute shrinkage and selection operator multivariate logistic regression model was used to generate specific algorithms and discriminate control subjects from patients with differ-ent kinds of cancer. The final predictive models reached the following performance: by using 11 compounds, patients with lung adenocarcinoma were identified with a sensitivity of 86% and specificity of 84%; nine compounds allowed us to identify patients with lung squamous cell car-cinoma with a sensitivity of 88% and specificity of 84%; patients with colon adenocarcinoma could be identified with a sensitivity of 96% and a specificity of 73% using a model comprising 13 volatile compounds. The different alveolar profiles of volatile compounds, obtained from pa-tients with three different kinds of cancer, suggest dissimilar biological-biochemistry condi-tions; each kind of cancer has probably got a specific alveolar profile.

Product ID:

119180

Handle IRIS:

11562/1035480

Last Modified:

November 11, 2022

Bibliographic citation:

Politi, Leonardo; Monasta, Lorenzo; Rigressi, Maria Novella; Princivalle, Andrea; Gonfiotti, Alessandro; Camiciottoli, Gianna; Perbellini, Luigi, Discriminant Profiles of Volatile Compounds in the Alveolar Air of Patients with Squamous Cell Lung Cancer, Lung Adenocarcinoma or Colon Cancer «MOLECULES» , vol. 26 , n. 3 , 2021 , pp. 1-22

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