Publications

Authors:

Munari, Enrico; Mariotti, Francesca R; Quatrini, Linda; Bertoglio, Pietro; Tumino, Nicola; Vacca, Paola; Eccher, Albino; Ciompi, Francesco; Brunelli, Matteo; Martignoni, Guido; Bogina, Giuseppe; Moretta, Lorenzo

Title:

PD-1/PD-L1 in Cancer: Pathophysiological, Diagnostic and Therapeutic Aspects

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN of journal:

1422-0067

N° Volume:

22

Number or Folder:

10

Page numbers:

1-18

Keyword:

NK cells; PD-1; PD-L1; cancer; glucocorticoids; immunotherapy

Short description of contents:

Immune evasion is a key strategy adopted by tumor cells to escape the immune system while promoting their survival and metastatic spreading. Indeed, several mechanisms have been developed by tumors to inhibit immune responses. PD-1 is a cell surface inhibitory receptor, which plays a major physiological role in the maintenance of peripheral tolerance. In pathological conditions, activation of the PD-1/PD-Ls signaling pathway may block immune cell activation, a mechanism exploited by tumor cells to evade the antitumor immune control. Targeting the PD-1/PD-L1 axis has represented a major breakthrough in cancer treatment. Indeed, the success of PD-1 blockade immunotherapies represents an unprecedented success in the treatment of different cancer types. To improve the therapeutic efficacy, a deeper understanding of the mechanisms regulating PD-1 expression and signaling in the tumor context is required. We provide an overview of the current knowledge of PD-1 expression on both tumor-infiltrating T and NK cells, summarizing the recent evidence on the stimuli regulating its expression. We also highlight perspectives and limitations of the role of PD-L1 expression as a predictive marker, discuss well-established and novel potential approaches to improve patient selection and clinical outcome and summarize current indications for anti-PD1/PD-L1 immunotherapy.

Product ID:

121267

Handle IRIS:

11562/1044330

Last Modified:

November 11, 2022

Bibliographic citation:

Munari, Enrico; Mariotti, Francesca R; Quatrini, Linda; Bertoglio, Pietro; Tumino, Nicola; Vacca, Paola; Eccher, Albino; Ciompi, Francesco; Brunelli, Matteo; Martignoni, Guido; Bogina, Giuseppe; Moretta, Lorenzo, PD-1/PD-L1 in Cancer: Pathophysiological, Diagnostic and Therapeutic Aspects «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES» , vol. 22 , n. 10 , 2021 , pp. 1-18

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