Publications

Authors:

Bonora, Enzo; Fedeli, Ugo; Schievano, Elena; Trombetta, Maddalena; Saia, Mario; Scroccaro, Giovanna; Tacconelli, Evelina; Zoppini, Giacomo

Title:

SARS-CoV-2 and COVID-19 in diabetes mellitus. Population-based study on ascertained infections, hospital admissions and mortality in an Italian region with ∼5 million inhabitants and ∼250,000 diabetic people

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Nutrition in Metabolic and Cardiovascular Diseases

ISSN of journal:

0939-4753

N° Volume:

31

Number or Folder:

9

Page numbers:

2612-2618

Keyword:

COVID-19; Diabetes; Hospital admission; Mortality; SARS-CoV-2 infection

Short description of contents:

Background and aims: Diabetes conveys an increased risk of infectious diseases and related mortality. We investigated risk of ascertained SARS-CoV-2 infection in diabetes subjects from the Veneto Region, Northeastern Italy, as well as the risk of being admitted to hospital or intensive care unit (ICU), or mortality for COVID-19. Methods and results: Diabetic subjects were identified by linkage of multiple health archives. The rest of the population served as reference. Information on ascertained infection by SARS-CoV-2, admission to hospital, admission to ICU and mortality in the period from February 21 to July 31, 2020 were retrieved from the regional registry of COVID-19. Subjects with ascertained diabetes were 269,830 (55.2% men; median age 72 years). Reference subjects were 4,681,239 (men 48.6%, median age 46 years). Ratios of age- and gender-standardized rates (RR) [95% CI] for ascertained infection, admission to hospital, admission to ICU and disease-related death in diabetic subjects were 1.31 [1.19-1.45], 2.11 [1.83-2.44], 2.45 [1.96-3.07], 1.87 [1.68-2.09], all p < 0.001. The highest RR of ascertained infection was observed in diabetic men aged 20-39 years: 1.90 [1.04-3.21]. The highest RR of ICU admission and death were observed in diabetic men aged 40-59 years: 3.47 [2.00-5.70] and 5.54 [2.23-12.1], respectively. Conclusions: These data, observed in a large population of ∼5 million people of whom ∼250,000 with diabetes, show that diabetes not only conveys a poorer outcome in COVID-19 but also confers an increased risk of ascertained infection from SARS-CoV-2. Men of young or mature age have the highest relative risks.

Product ID:

122139

Handle IRIS:

11562/1047747

Last Modified:

January 30, 2025

Bibliographic citation:

Bonora, Enzo; Fedeli, Ugo; Schievano, Elena; Trombetta, Maddalena; Saia, Mario; Scroccaro, Giovanna; Tacconelli, Evelina; Zoppini, Giacomo, SARS-CoV-2 and COVID-19 in diabetes mellitus. Population-based study on ascertained infections, hospital admissions and mortality in an Italian region with ∼5 million inhabitants and ∼250,000 diabetic people «Nutrition in Metabolic and Cardiovascular Diseases» , vol. 31 , n. 9 , 2021 , pp. 2612-2618

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