Publications

Authors:

Bernardelli, Andrea; Schena, Alberto; Savoldi, Alessia; Colato, Chiara; Baretta, Valentina; D'Alessandro, Emiliano; Zamboni, Giulia; Shoushtari Zadeh Naseri, Mehrdad; Favaro, Flavio; Peracchi, Marta; Schena, Donatella; Andreini, Angelo; Cesaro, Simone; Tecchio, Cristina

Title:

A Disseminated Mycobacterium Abscessus Infection in a Patient Affected by Pulmonary Graft versus Host Disease: Case Report with a Revision of Literature

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

JOURNAL OF CLINICAL MEDICINE

ISSN of journal:

2077-0383

N° Volume:

11

Number or Folder:

9

Page numbers:

1-8

Keyword:

Mycobacterium abscessus complex; haploidentical hematopoietic stem cell transplant; nontuberculous mycobacteria; pulmonary chronic graft versus host disease

Short description of contents:

Mycobacterium abscessus complex, hereinafter Mab, is a taxonomic group of rapidly growing, nontuberculous mycobacteria (NTM). Despite major advances in understanding virulence, pathogenicity and mechanism of antibiotic resistance, Mab remains a significant cause of pulmonary and extra-pulmonary disease. Herein, we describe a disseminated, macrolide-resistant, Mab subspecies abscessus infection occurring in a severely immune-compromised 34-year-old allotransplanted female patient affected by pulmonary chronic graft versus host disease (cGVHD). The infection was characterized by hematogenous spread, and besides lungs, it involved skin, and soft tissues, resulting in a highly debilitating, painful, and finally fatal disease. Our case describes the severe impact of Mab infections in the setting of allogeneic hematopoietic stem cells transplant (alloHSCT) and related complications. It also highlights the unmet need of preventive and surveillance measures together with the urgency of developing effective vaccines and drugs against emerging NTM. The scarce literature regarding Mab infections in alloHSCT patients is also reviewed.

Product ID:

126934

Handle IRIS:

11562/1065400

Last Modified:

November 15, 2022

Bibliographic citation:

Bernardelli, Andrea; Schena, Alberto; Savoldi, Alessia; Colato, Chiara; Baretta, Valentina; D'Alessandro, Emiliano; Zamboni, Giulia; Shoushtari Zadeh Naseri, Mehrdad; Favaro, Flavio; Peracchi, Marta; Schena, Donatella; Andreini, Angelo; Cesaro, Simone; Tecchio, Cristina, A Disseminated Mycobacterium Abscessus Infection in a Patient Affected by Pulmonary Graft versus Host Disease: Case Report with a Revision of Literature «JOURNAL OF CLINICAL MEDICINE» , vol. 11 , n. 9 , 2022 , pp. 1-8

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