Publications

Authors:

Longo, Chiara; Geraci, Luca; Tomaiuolo, Luisa; Autelitano, Daniele; Todesco, Marco; Rossi, Vittoria; Cicalò, Francesco; Verrengia, Francesco; D'Onofrio, Mirko

Title:

Radiogenomics of Pancreatic Ductal AdenoCarcinoma

Year:

2022

Type of item:

Poster

Tipologia ANVUR:

Poster

Language:

Inglese

Format:

Elettronico

Congresso:

ECR 2022 - ESR - European Society of Radiology

Place:

Austria Center Vienna, Austria

Period:

13/07/2022 – 17/07/2022

Page numbers:

1-1

Keyword:

Artificial Intelligence, Oncology, Pancreas, CT, MR, Experimental investigations, Outcomes analysis, Radiobiology, Tissue characterisation

Short description of contents:

The aim of our study was to perform a simplified radiomic analysis of pancreatic ductal adenocarcinoma based on qualitative and quantitative tumor features and to compare the results with different muted genes, in particular with KRAS and TP53 expression, in order to predict the outcome and, in future, to direct the therapeutic path.

Note:

Pancreatic cancer has a very poor prognosis and its most frequent isotype is represented by pancreatic ductal adenocarcinoma (PDAC). Despite advances in early diagnosis and multimodal treatments, the prognosis for patients with PDAC remains poor, with a 5-year survival rate that lies around 8%. According to genomics, there are certain genes often mutated in PDAC’s carcinogenesis: KRAS, CDKN2a/INK4a, TP53, and DPC4/SMAD4. In particular we focused on the presence or absence of KRAS mutation as it is the most frequent mutated oncogene (95%) that determine an increased growth and survival of tumoral cells. Secondly we analyzed TP53 expression as it is demonstrated that it is inactivated in up to 75% of the PDAC. The aim of our study was to perform a simplified radiomic analysis of pancreatic ductal adenocarcinoma based on qualitative and quantitative tumor features and to compare the results with different muted genes, in particular with KRAS and TP53 expression, in order to predict the outcome and, in future, to direct the therapeutic path. At our knowledge, this is the first study that looks for radiogenomic data for PDAC through RM imaging.

Web page:

https://dx.doi.org/10.26044/ecr2022/C-14768

Product ID:

132157

Handle IRIS:

11562/1075328

Last Modified:

February 23, 2023

Bibliographic citation:

Longo, Chiara; Geraci, Luca; Tomaiuolo, Luisa; Autelitano, Daniele; Todesco, Marco; Rossi, Vittoria; Cicalò, Francesco; Verrengia, Francesco; D'Onofrio, Mirko, Radiogenomics of Pancreatic Ductal AdenoCarcinoma  in EPOS , Proceedings of "ECR 2022 - ESR - European Society of Radiology" , Austria Center Vienna, Austria , 13/07/2022 – 17/07/2022 , 2022 , pp. 1-1

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